background: extended spectrum β-lactamases (esbls) and ampc β-lactamases enzyme are major sources of resistance to β-lactam antibiotics especially in enterobacteriaceae such as escherichia coli and klebsiella pneumoniae. increasing frequency of the co-existence of esbls with ampc-β-lactamases in bacteria is a serious threat for treating bacterial infections. conclusions: outbreak of isolates co...

background  and  objectives: pseudomonas  aeruginosa is responsible for devastating nosocomial infections among severely burn patients. class c of cephalosporinase (ampc-β-lactamases) is important cause of multiple β-lactam resistance in p. aeruginosa . the aim of this study was to detect the ampc-β-lactamases producing isolates among carbapenem resistant p.  aeruginosa isolated from burn patie...

BACKGROUND & OBJECTIVES AmpC β-lactamases are clinically significant since these confer resistance to cephalosporins in the oxyimino group, 7-α methoxycephalosporins and are not affected by available β-lactamase inhibitors. In this study we looked for both extended spectrum β-lactamases (ESBL) and AmpC β-lactamases in Klebsiella pneumoniae clinical isolates. METHODS One hundred consecutive, n...

Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae...

BACKGROUND AND OBJECTIVES Pseudomonas aeruginosa is responsible for devastating nosocomial infections among severely burn patients. Class C of cephalosporinase (AmpC-β-lactamases) is important cause of multiple β-lactam resistance in P. aeruginosa. The aim of this study was to detect the AmpC-β-lactamases producing isolates among carbapenem resistant P. aeruginosa isolated from burn patient. ...

background: ampc type β-lactamases are commonly isolated from extended-spectrum cephalosporin-resistant gram-negative bacteria. also, resistance appeared in bacterial species not naturally producing ampc enzymes. therefore, a standard test for the detection of the plasmid-mediated ampc enzyme and new breakpoints for extended spectrum cephalosporins are urgently necessary. objectives: to detect ...

The AmpC β-lactamases are clinically important because they confer resistance to the narrow-, expandedand the broad-spectrum cephalosporins, the β-lactam-β-lactamase inhibitor combinations and aztreonam. The clinical microbiology laboratories should be able to detect the bacterial strains which produce AmpC, since these strains may appear to be susceptible to a particular β-lactam antibiotic in...

conclusions a high prevalence of multiple β-lactamase production was observed among the ampc producers (60%), of which the majority co-produced ampc and mbl. the current study results showed correlation between β-lactamase production and the presence of antibiotic resistance genes in the isolates. results all isolates were multidrug resistant. ampc, esbl and mbl production were observed in 35 (...

BACKGROUND Pseudomonas aeruginosa is one of the most common causes of nosocomial infections. Resistance of P. aeruginosa to β-lactam antibiotics may be the result of acquired resistance through mutation and over production of various antibiotic inactivating enzymes. This research aimed to determine the prevalence of extended-spectrum β-lactamases (ESBL) and metallo β-lactamase (MBL) production ...

Environmental microorganisms represent the most relevant reservoir of resistance to antibiotics in the community, and this is due in part to the undue exposure of these organisms to antimicrobial agents. AmpC β-lactamases are clinically important cephalosporinases encoded on the chromosomes of bacteria in the Enterobacteriaceae family and some non-enteric bacteria including Pseudomonas aerugino...