The aim of this study was to trace D-amphetamine toxicity in isolated rat hepatocytes and to elucidate a possible involvement of CYP3A in the mechanisms of its toxicity. To this end, male Wistar rats were treated with nifedipine (5 mg kg(-1) i.p., 5 days), a substrate and inducer of CYP3A. Hepatocytes isolated from nifedipine-treated and control rats were incubated with D-amphetamine at a conce...

Previous research in this laboratory has shown that a diet of intermittent excessive sugar consumption produces a state with neurochemical and behavioral similarities to drug dependency. The present study examined whether female rats on various regimens of sugar access would show behavioral cross-sensitization to a low dose of amphetamine. After a 30-min baseline measure of locomotor activity (...

Abstract Introduction Cocaineand amphetamine-regulated transcript peptides have been implicated in the endocrine and autonomic regulation, food intake and anxiety. Anatomical studies demonstrate that cocaineand amphetamine-regulated transcript mRNA and peptides are expressed intensely in the hypothalamo-pituitary-adrenal gland axis and sympatho-adrenal system. In parallel with the anatomical st...

Hair analysis is a reliable tool for detecting long-term exposure to illegal drugs, including amphetaminetype stimulants, over periods from a few weeks to a few months, depending on the length of the hair used for analysis. Between 2000 and 2012, over 600 hair samples were analysed at the Institute for Medical Research and Occupational Health, Croatia (IMROH) for the presence of amphetamine-typ...

BACKGROUND The neurotransmitter norepinephrine has been implicated in psychiatric and neurodegenerative disorders. Examination of synaptic norepinephrine concentrations in the living brain may be possible with positron emission tomography (PET), but has been hampered by the lack of suitable radioligands. METHODS We explored the use of the novel α2C-adrenoceptor antagonist PET tracer [(11)C]OR...

BACKGROUND We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET). METHODS Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a "high" ...

of the Dissertation.....................................................................ii Acknowledgments.........................................................................................................iv List of Figures................................................................................................................x Introduction.............................................

BACKGROUND Laboratory experiments conducted since the 1940s show that amphetamine combined with task-relevant experience improves postbrain injury behavioral outcomes. Several small clinical trials evaluated the approach as a means of improving poststroke recovery. RESULTS In laboratory studies, the effect of amphetamine on recovery depends on the location and extent of brain injury, the dosi...

Use of amphetamine and methamphetamine is widespread in the general population and common among patients with psychiatric disorders. Amphetamines may induce symptoms of psychosis very similar to those of acute schizophrenia spectrum psychosis. This has been an argument for using amphetamine-induced psychosis as a model for primary psychotic disorders. To distinguish the two types of psychosis o...

Please be advised that this information was generated on 2016-05-01 and may be subject to change. A bstract Previous studies have shown that stressors at­ tenuate LiCl-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies ex­ amined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA. Experiment 1 demonstrated that exposure...