Objective(s): Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. Materials and Methods: Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group went through no surgical or dietary intervention. At the 4th week of study S...

objective(s): neuroprotective effect of creatine (cr) against β-amyloid (aβ) is reported in an in vitro study. this study investigated the effect of cr supplementation on β-amyloid toxicity in vivo. materials and methods: thirty two, male wistar rats were divided into 4 groups. during ten weeks of study, control group went through no surgical or dietary intervention. at the 4th week of study sh...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Background Early detection of amyloid beta (Aβ) accumulation has become important as Aβ begins before clinical symptoms appear. Previous longitudinal studies Aβ-negative (Aβ-) people have shown that some them convert to amyloid-positive (Aβ+) and others remain amyloid-negative. The effects conversion Aβ+ not been extensively investigated, yet. aim the study is investigate cognitive changes acco...

background and objectives: alzheimer's disease (ad) as a neurodegenerative disorder is the most common form of dementia in the elderly. according to the amyloid hypothesis, accumulation of amyloid beta (aβ) plaques, which are mostly constituted of aβ peptide aggregates, triggers pathological cascades that lead to neuronal cell death. thus, modulation of aβ toxicity is the hopeful therapeut...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Interactions of 3,3',4,4'-tetrahydroxybiphenyl (BPT) and three isomeric 3,3",4,4"-tetrahydroxyterphenyls (OTT, MTT, PTT) with Alzheimer’s amyloid-β peptide (Aβ) were studied by molecular dynamics simulation and molecular docking. Structural parameters such as Root-mean-square derivations (RMSD), radial distribution function (RDF), helix percentage and other physical parameters were obtained. Th...

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. The aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of AD. Methods: Adult male Albino Wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned t...

alzheimer disease (ad) is a neurodegenerative disorder marked by cognitive and behavioral impairment. amyloid beta (aβ) peptides are involved in ad as the main component of amyloid plaques found in the brain. recent in vivo and in vitro studies have shown that there is a lot of substances that alter aβ pathogenesis of ad. aβ induces toxicity lead to increasing ros. in the other hand, 5-ht6 and ...