Mutations in PSEN genes, which encode presenilin proteins, cause familial early-onset Alzheimer's disease (AD). Transgenic mouse models based on coexpression of familial AD-associated presenilin and amyloid precursor protein variants successfully mimic characteristic pathological features of AD, including plaque formation, synaptic dysfunction, and loss of memory. Presenilins function as the ca...

BACKGROUND Amyloid positron emission tomography (PET) has become an important tool to identify amyloid-β (Aβ) pathology in Alzheimer's disease (AD) patients. Here, we determined the diagnostic value of the amyloid PET tracer [(18)F]flutemetamol in relation to Aβ pathology at autopsy. METHODS [(18)F]flutemetamol PET was carried out in a cohort of 68 patients included in a [(18)F]flutemetamol a...

The brains of patients with Alzheimer's disease (AD) contain abundant plaques composed of beta-amyloid (Abeta) peptides. It has been assumed that amyloid plaques and soluble Abeta oligomers induce neuronal pathology in AD; however, the mechanism by which amyloid mediates pathological effects is not clearly understood. In vivo calcium (Ca2+) imaging and array tomography studies with AD mouse mod...

The development of early diagnostic and prognostic tools for the visualization of amyloid-β (Aβ) deposits is one important focus of current imaging research. In patients with Alzheimer's disease (AD), non-invasive and efficient detection of soluble and aggregated Aβ is important to determine the immediate success of intervention trails. The novel near infrared-fluorescence (NIRF) probe THK-265 ...

Advances in translational research provide key opportunities to explore the physiological and pathological effects of sleep different neurodegenerative diseases. Recent findings suggest that sleep-wakefulness dysfunctions may predispose disorders such as Alzheimer’s disease (AD), vice versa. New theories on link between β-amyloid tau secretion, accumulation clearance, its interaction with hypoc...

This work models the progression of beta-amyloid pathology according to Small's synaptic scaling theory in an updated version of Ruppin and Reggia's associative neural network model of Alzheimer's disease, leading to a self-reinforcing cascade of damage. Using an information theoretic approach, it is shown that the simulated beta-amyloid pathology initially selectively targets neurons with low ...

We report optical-resolution photoacoustic microscopy (OR-PAM) for in vivo imaging of amyloid plaques in an Alzheimer's disease mouse model. Validation using conventional fluorescence microscopy and multiphoton microscopy shows that OR-PAM has sufficient sensitivity and spatial resolution to identify amyloid plaques in living brains. In addition, with dual-wavelength OR-PAM, the three-dimension...