Many questions about analgesic nephropathy (AN) lack clear-cut answers. We present available evidence for and against proposed answers to many of these questions. These include: (1) Is acetaminophen (AC) nephrotoxic when taken as the sole analgesic? (2) Is the combination of acetylsalicylic acid (ASA) and AC more nephrotoxic than AC taken alone, and if so, why? (3) What are the minimum doses an...

Acetaminophen is an effective mild analgesic and antipyretic agent. In double-blind, controlled experimental pain studies of short duration, acetaminophen is superior to placebo and produces analgesia comparable to that produced by aspirin. The frequency of adverse reactions to therapeutic doses of acetaminophen is low, as is that of aspirin. Overdosage with acetaminophen, however, may result i...

objective: premna integrifolia linn (family: verbenaceae) synonym of premna serratifolia has tremendous medicinal value. preliminary pharmacological studies were performed on the methanolic extract of premna integrifolia (mepi) bark to investigate neuropharmacological, analgesic, and anti-inflammatory activities. materials and methods: neuropharmacology study was done by open field and hole cro...

introduction: pain may be described as a sensation of hurt or strong discomfort and is the body's way of sending message to the brain that an injury has occurred. pain medicines block these messages or reduce their effect on the brain. accurate administration of analgesia have a long –lasting effect on children whole experience of medical care and affects parents' and children's ...

conclusions it seems that propofol and fentanyl can be used as a safe and fast combination for psa in the reduction of asd. patients and methods the subjects in this clinical trial consisted of 48 patients with asd who were randomly assigned to midazolam/fentanyl and propofol/fentanyl groups for psa. the two groups were compared to the time interval between injection and induction of sedation (...

extracts obtained from the petals of rosa damascena (rosaceae) are used in iranian folk medicine as remedies for the treatment of some inflammatory diseases. in this study the hydroalcoholic extract and essential oil of the plant were investigated for its possible anti-inflammatory and analgesic activities. the extract was administered at the doses (p.o.) of 250, 500 and 1000?mg/kg and the dose...

BACKGROUND Reduction in consumption of opioid rescue medication is often used as an endpoint when investigating analgesic efficacy of drugs by adjunct treatment, but appropriate methods are needed to analyze analgesic consumption in time. Repeated time-to-event (RTTE) modeling is proposed as a way to describe analgesic consumption by analyzing the timing of consecutive analgesic events. METHO...

Pain is an ill-defined, disabling accompaniment of many medical conditions. It is often evoked by an external and internal noxious stimulus. It affects millions of people suffering with depression and other psychiatric disorders. Most of the antidepressants are having analgesic capacity to treat the pain by inhibiting nociceptive stimuli by increasing the seratonergic and noradrenergic transmis...

derivatives of pyridine-4-one are iron chelators with various biological activities including antifungal, anti-malarial, antiviral, anti-inflammatory and analgesic activities. this study was aimed to evaluate the analgesic effect of four new derivatives of 3-hydroxy pyridine-4-one in animal models. acetic acid-induced writhing and formalin tests were used to assess the analgesic activity in mal...

Loperamide, a mu opioid receptor agonist, which is commonly used as an antidiarrhoeal agent has been reported to possess analgesic activity after intrathecal administration. However, the exact analgesic profile, i.e., onset, duration and intensity of analgesia in relation to morphine is not fully known. In the present study, the acute analgesic effect of loperamide (5 microg) was compared with ...