HC-04 cells were evaluated as an in vitro model for mechanistic study of changes in the function of hepatic CYP3A during virus infection. Similar to in vivo observations, infection with a first generation recombinant adenovirus significantly inhibited CYP3A4 catalytic activity in an isoform-specific manner. Virus (MOI 100) significantly reduced expression of the retinoid X receptor (RXR) by 30%...

Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related deaths in the United States, and is projected to be second by 2025. It has the worst survival rate among all major cancers. Two pressing needs for extending life expectancy of affected individuals are the development of new approaches to identify improved therapeutics, addressed herein, and the identification o...

PhIlIP g. CRaNDall,1* CORlISS a. O’BRyaN,1 ElIzaBETh M. MaRTIN,2 SEaN PENDlETON,1 ERIN ShaNNON,1 JOhN MaRCy1,3 and STEvEN C. RICKE1 1Dept. of Food Science and Center for Food Safety, University of arkansas, Fayetteville, aR 72701-1201, USa; 2Dept. of Biological & agricultural Engineering, University of arkansas, Fayetteville, aR 72701-1201, USa; 3Dept. of Poultry Science, University of arkansas...

Glutamate is the major excitatory neurotransmitter in the brain. It can cause neuronal cell damage in the context of oxidative stress. BJ-1201 is a derivative of the compound aminopyridinol, which is known for its antioxidant activity. In this study, we examined the effect of BJ-1201, a 6-(diphenylamino)-2,4,5-trimethylpyridin-3-ol compound, on neuroprotection in HT22 cells. Our data showed tha...

Discussed are recent developments in biocomputing, outlining research progress from single enzyme-logic operations to systems of scaled-up complexity. Examples of specific logic operations are presented and strategies for system optimization to suppress the spread of noise in enzyme-logic networks are discussed. Special attention is given to electrochemical signal-transducing nanobiointerfaces,...

From the *Biological Carcinogenesis and Development Program, PRI/DynCorp, Frederick, Maryland 21702-1201; the r of Pathology and the Committee on Immunology, University of Chicago, Chicagg Illinois 60637; the gDepartment of Biology, University of California, San Diego, La Jolla, California 92093; the IIDepartment of Biology and Cancer Center, University of California at Berkeley, Berkeley, Cali...

Two porous, chiral metal-organic frameworks (MOFs), Ca14(l-lactate)20(acetate)8(C2H5OH)(H2O) (MOF-1201) and Ca6(l-lactate)3(acetate)9(H2O) (MOF-1203), are constructed from Ca2+ ions and l-lactate [CH3CH(OH)COO-], where Ca2+ ions are bridged by the carboxylate and hydroxyl groups of lactate and the carboxylate group of acetate to give a three-dimensional arrangement of Ca(-COO, -OH) polyhedra su...

The aim of this study was to investigate anti-inflammatory and antioxidant effects of preparation EM 1201 on adjuvant induced arthritis in rats. Material and methods. Adjuvant arthritis (AA) was induced in 24 female Wistar rats by intradermal injection of complete Freund’s adjuvant into the left hind paw. The course of disease and pro-/antioxidant status of blood serum in response to the prophy...