P ROGNOSIS in aplastic anemia has improved since the introduction of testosterone therapy.1 This androgenic hormone has proved very useful in the treatment of children with congenital and acquired aplastic anemia,1-5 but appears to be less effective in adults with the same disorder.#{176} Oxymetho1one79 and other related steroids4’1015 have recently been used in place of testosterone with good ...

BACKGROUND The inappropriate use of anabolic androgenic steroids (AAS) was originally a problem among athletes but AAS are now often used in nonsport situations and by patients attending regular addiction clinics. The aim of this study was to improve understanding of the development of multiple drug use in patients seeking treatment at an addiction clinic for AAS-related problems. METHODS We ...

Substituted phenylazo and phenylazoxy compounds were systematically prepared and their anti-androgenic activity was measured in terms of (1) the growth-inhibiting effect on an androgen-dependent cell line, SC-3, and (2) the binding affinity to nuclear androgen receptor. Generally, azo/azoxy compounds showed cell toxicity, and the growth-inhibiting effects on SC-3 cells correlated with the toxic...

The potential mechanisms involving the genesis and growth of androgen-independent prostate cancer include super-expression of the androgen receptor (AR), in an attempt to compensate for the low androgenic plasma levels and mutations of this specific receptor, which could determine resistance to anti-androgenic therapy. However, most advanced prostate tumors have no mutations or amplifications o...

BACKGROUND The European chemicals' legislation REACH aims to protect man and the environment from substances of very high concern (SVHC). Chemicals like endocrine disruptors (EDs) may be subject to authorization. Identification of (potential) EDs with regard to the environment is limited because specific experimental assessments are not standard requirements under REACH. Evidence is based on a ...

background: the selection of pre-embryos for transferred is based on morphological appearance. but some poor quality cleaved embryos also can be cultured to the blastocyst stage and implanted. objective: to assess the clinical pregnancy outcomes of blastocyst transfer which developed from poor quality embryos. materials and methods: a total of 109 cleaved embryos with poor quality were cultured...

Nandrolone, or 19-Nortestosterone, is one of the most widely used synthetic anabolic-androgenic steroids by athletes who need power and muscle strength. It is derived from testosterone, the main sex hormone produced in man. A small chemical modification makes nandrolone more anabolic than androgenic and accounts for its widespread misuse in sport. Testosterone has an anabolic:androgenic ratio o...

OBJECTIVE Although androgenic alopecia is recognised to be a symptom of polycystic ovary syndrome (PCOS), it is not known whether polycystic ovaries (PCO) and associated endocrine abnormalities are present in patients who present with alopecia as a primary complaint. We therefore set out to determine the strength of the association between androgenic alopecia and PCO. We examined the prevalence...