introduction as a tumor grows, the demand for oxygen and nutrients increases and it grows further if acquires the ability to induce angiogenesis. in this study, we aimed to present a two-dimensional continuous mathematical model for avascular tumor growth, coupled with a discrete model of angiogenesis. materials and methods in the avascular growth model, tumor is considered as a single mass, wh...

background angiogenesis is an important biological process involved in the proliferation of endothelial cells, tumor growth and metastasis. vascular endothelial growth factor (vegf) is considered as a prominent regulator of angiogenesis which exerts the aforementioned effect(s) through its respective receptors (vegfr1 and vegfr2). vegf receptors are targeted as a therapeutic candidate for cance...

Background: CD105 is highly expressed on human activated endothelial cells (ECs), an important component of the TGF-β1 receptor complex and essential for angiogenesis. expression up-regulated in ECs potential marker cancer prognosis. Materials Methods: In vitro rat myoblasts transfected with L-CD105 S-CD105 transfectants. The transfectants were treated angiogenesis study. Results: affects cell ...

Abstract Colorectal cancer (CRC) is one of the most common malignancies worldwide. Circular RNAs (circRNAs) are involved in pathological processes, especially development cancers, but roles circRNAs CRC largely unknown. In this study, we investigated role and underlying mechanisms Circ_0030998 cell proliferation angiogenesis. We found that was upregulated tissues cells, its upregulation related...

Vascular endothelial growth factors (VEGFs) are the family of extracellular signaling proteins involved in processes angiogenesis. VEGFA overexpression and altered regulation pathways lead to pathological angiogenesis, which contributes progression various diseases, such as age-related macular degeneration cancer. Monoclonal antibodies decoy receptors have been extensively used anti-angiogenic ...

Angiogenesis is a fundamental process in various physiologic and pathologic processes. The ability to visualize and quantify angiogenesis will allow early diagnosis and monitoring for clinical determination of angiogenesis states before, during, and after adjuvant antiangiogenic and therapeutic angiogenesis treatments.

Heme-oxygenases (HOs) catalyze the conversion of heme into carbon monoxide and biliverdin. HO-1 is induced during hypoxia, ischemia/reperfusion, and inflammation, providing cytoprotection and inhibiting leukocyte migration to inflammatory sites. Although in vitro studies have suggested an additional role for HO-1 in angiogenesis, the relevance of this in vivo remains unknown. We investigated th...

the aim of present study was to investigate whether food restriction combined with exercise training could attenuate the oxidative stress and promote angiogenesis in a rat model of heart failure. 50 male wistar rats weighing 250-300 g were randomly divided into 5 groups including: 1) sham; they were fed ad libitum food, n=10. 2) heart failure group; 3) exercise group; they run on a treadmill 5 ...

background: minoxidil has been reported to inhibit in vitro fibroblast proliferation and lysyl hydroxylase activity, a key enzyme in collagen biosynthesis. these in-vitro effects proposed minoxidil to be a potential antifibrotic agent. the present study aimed to investigate the effects of minoxidil gel on wound healing procedure in a second-degree burn model in rats.  materials and methods: wis...

human bone marrow derived mesenchymal stem cells (hbmscs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. in this study, the differentiation of hbmscs into endothelial like-cells was induced in presence of vascular endothelial growth factor (vegf) and insulin-like growth factor (igf-1). the differentiated endothelial cells were exam...