Endothelial cell migration is an essential aspect of tumor angiogenesis. Rac1 activity is needed for cell migration in vitro implying a requirement for this molecule in angiogenesis in vivo. However, a precise role for Rac1 in tumor angiogenesis has never been addressed. Here we show that depletion of endothelial Rac1 expression in adult mice, unexpectedly, has no effect on tumor growth or tumo...

Angiogenesis, i.e., the formation of new blood vessels from pre-existing endothelial cell (EC)-lined vessels, is critical for tissue development and also contributes to neovascularization-related diseases, such as cancer. Vascular growth factor (VEGF) bone morphogenetic proteins (BMPs) are among many secreted cytokines that regulate EC function. While several pharmacological anti-angiogenic age...

BACKGROUND Many angiogenic factors require endothelium-derived nitric oxide (NO) to exert their effects. Recently, an endogenous competitive antagonist of NO synthase has been characterized: asymmetric dimethylarginine (ADMA). Elevated plasma levels of ADMA reduce NO synthesis in hypercholesterolemia. Accordingly, we hypothesized that hypercholesterolemia impairs angiogenesis by an ADMA-depende...

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Chu LH, Rivera CG, Popel AS, Bader JS. Constructing the angiome: a global angiogenesis protein interaction network. Physiol Genomics 44: 915–924, 2012. First published August 21, 2012; doi:10.1152/physiolgenomics.00181.2011.—Angiogenesis is the formation of new blood vessels from pre-existing microvessels. Excessive and insufficient angiogenesis have been associated with many diseases including...

To characterize concentrated growth factors (CGFs) in vivo, we examined the degradation of implanted CGF rabbits. Untreated (U-CGF) and compressed (C-CGF) were subcutaneously into dorsum. Histological analyses showed that U-CGF C-CGF induced very few inflammatory cells subsequently degraded with dendritic invasion granulation tissue. The histopathologically remained for longer term than U-CGF. ...

Autophagy, the major lysosomal pathway for degradation and recycling of cytoplasmic materials, is increasingly recognized as a player in endothelial cell (EC) biology vascular pathology. Particularly solid tumors, tumor microenvironmental stress such hypoxia, nutrient deprivation, inflammatory mediators, metabolic aberrations stimulates autophagy tumor-associated blood vessels. Increased ECs ma...

objectives : squamous cell carcinoma (scc) is the most common malignant neoplasm of the oral cavity and a public health threat. tumor progression is believed to be influenced by angiogenesis as well as tumor cell proliferation; however, the correlation of these two factors in tongue scc still remains unclear. this study aimed to assess the correlation of these two factors in tongue scc. materia...

objective(s): herbal medicines are promising cancer preventive candidates. it has been shown that punica granatum l. could inhibit angiogenesis and tumor invasion. in this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (ppe) is partly attributable to peroxisome proliferator-activated receptors (ppars) activation in the human umbilical vein endothelial cell...

background: angiogenesis gene therapy has long been sought as a novel alternative treatment for restoring the blood flow and improving the contractile function of the ischemic heart in selected clinical settings. angiogenic fibroblast growth factor-1 (fgf-1) is a promising candidate for developing a promising gene therapy protocol due to its multipotent ability to stimulate endothelial cell (ec...