Introduction: Angiotensin converting enzyme (ACE) is an exopeptidase that converts Angiotensin I to Angiotensin II. Angiotensin II is a potent vasoconstrictor and releases aldosterone, and have a critical role in hypertension. In this study, ACE insertion / deletion (I/D) polymorphism and ACE activity was determined in patients with coronary artery disease (CAD) and normal subjects. The corr...

To investigate the effects of angiotensin converting enzyme 2 and genes on cardiac remodeling process in heart failure rats. 38 rats were randomly divided into sham-operated group (S group), (H group) exercise (HE group). An incremental load test was used to determine maximum running speed HE group, while S H groups maintained their daily activities. The structure function pathological changes ...

The paper presents the theoretical considerations on role of endocrine and metabolic alterations accompanying COVID-19 infection. These may be presumed basis following two observations. Firstly, virus SARS-CoV-2 responsible for infection uses an important renin–angiotensin system (RAS) element — angiotensin-converting enzyme 2 (ACE2) as a receptor protein entry into target cells and, in consequ...

Diabetic nephropathy (DN) is one of the major causes of end stage renal disease. Angiotensin converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) are preferred for delaying progression of DN. This study compared the preventive renal effects of telmisartan (10 mg/kg, p.o.), an ARB that completely blocks angiotensin action, and benazepril (5 mg/kg, p.o.), an ACE inhibitor, whi...

HIGHLIGHTS Ischemia-reperfusion triggers acute kidney injury due to reactive oxygen species. Quercetin is an antioxidant flavonoid that modulate the Rennin-Angiotensin System. prevents tubular cell death, oxidation, and mitochondrial depolarization. interacts with angiotensin AT1 receptor.

the activity of angiotension converting enzyme (ace; omim: 106180) in different brain regions of patients with schizophrenia changed, suggesting a possible involvement of ace in psychiatric disorders. genetic polymorphism of insertion/deletion (i/d; dbsnp rs4646994) in the gene encoding ace has been well defined.the present case-control study was performed on 363 (268 males, 95 females) in-pati...

introduction: the brain renin-angiotensin system (ras) has been reported having a pathological role in age-related impairment in learning and memory. therefore, angiotensin converting enzyme inhibitors (acei) are expected to have positive effects on memory. longtime treatment with captopril (an angiotensin converting enzyme inhibitor) significantly attenuates the age-related impairment in learn...

the effects of allium sativum on yogurt formation and subsequent storage (4°c, up to 28 days) on proteolysis, microbial activity, and inhibition of α-amylase, α-glucosidase and angiotensin-i converting enzymes were investigated in vitro. allium sativum yogurt showed higher rates of ph reduction and increment of titrable acid than control during the incubation at 41°c. highest proteolysis was ob...

conclusions traditional medicine based on certain plants could be of beneficial effects in hypertension treatment. results in total, 52 species out of the 135 (39%) screened, gave more than 50% ace inhibition. forty species were found to possess a high ace inhibiting ability and were low in their tannin content. materials and methods in the present study 135 plants used in traditional persian m...

background: this study was aimed to assess the effects of angiotensin ii (ang ii) supplementation to the in vitro maturation (ivm) and in vitro culture (ivc) media of vitrified-warmed ovine oocytes on their developmental competence and expression of na+/k+/atpase in resulting embryos. methods: the slaughterhouse-derived immature oocytes (n=1069) were randomly distributed into four experimental ...