This study aims to investigate the role of long non-coding RNA (lncRNA) HOX transcript antisense (HOTAIR) in regulation anoikis resistance ovarian cancer cells, a prerequisite for metastasis and chemoresistance cells. Ovarian SKOV3 cells were cultured an ultra-low attachment system establish model. The relationship between cellular capability HOTAIR expression level was studied by flow cytometr...

Malignant epithelial cells with metastatic potential resist apoptosis that normally occurs upon loss of anchorage from the extracellular matrix, a process termed "anoikis." Resistance to anoikis enables malignant cells to survive in an anchorage-independent manner, which leads to the formation of distant metastases. To understand the regulation of anoikis, we designed, automated, and conducted ...

This study aimed to explore the prognostic value of Anoikis-related genes (ANRGs) in colon cancer using bioinformatics and construct a model based on ANRGs. ANRGs integrated from GeneCard Harmonizome were used identify CRC subtypes for patients. The immune microenvironment (TME) between different was also investigated. Finally, line chart provided clinical use, decision curve analysis (DCA) per...

Anoikis is a form of apoptosis triggered by inadequate or inappropriate cell matrix contacts. Anoikis resistance has been utilized to isolate adult stem or progenitor cell populations from various tissues. The aim of this study was to characterize the stem or progenitor cell markers expressed in anoikis-resistant cells isolated from mouse colonic epithelium. Mouse colonic epithelial cells were ...

Human adenoid cystic carcinoma (ACC) is characterized by diffused invasion of the tumor into adjacent organs and early distant metastasis. Anoikis resistance and epithelial mesenchymal transition (EMT) are considered prerequisites for cancer cells to metastasize. Exploring the relationship between these processes and their underlying mechanism of action is a promising way to better understand A...

Abstract Objectives Anoikis plays an active role in the metastasis and progression of many tumors is emerging as a new target for tumor therapy. We aimed to develop anoikis-related risk model assess prognosis patients with bladder urothelial carcinoma (BLCA) explore its potential application value immunotherapy. Methods Patient expression data clinical were obtained from GEO TCGA database. Lass...

Malignant epithelial cells with metastatic potential resist apoptosis that normally occurs upon loss of anchorage from the extracellular matrix, a process termed ‘‘anoikis.’’ Resistance to anoikis enables malignant cells to survive in an anchorage-independent manner, which leads to the formation of distant metastases. To understand the regulation of anoikis, we designed, automated, and conducte...

BACKGROUND Resistance to anoikis, apoptosis triggered by a loss of cellular adhesion to the underlying extracellular matrix, is a hallmark of metastatic cancer. Previously we have shown re-establishment of CXCL12 expression in colorectal carcinoma cells inhibits metastasis by enhancing anoikis sensitivity. The objective of these studies was to define the signaling mechanisms regulating CXCL12-m...

Metastatic cancer cells are able to survive the loss of attachment to the extracellular matrix (ECM) by developing resistance to anoikis, a specialized form of apoptosis. Here we investigated resistance to anoikis in nasopharyngeal carcinoma cells (NPC). When detached in culture, the highly metastatic S18 NPC cell line exhibited strong resistance to anoikis, as compared to the poorly metastatic...

TLE1 is a Groucho-related transcriptional repressor protein that exerts survival and antiapoptotic function in several cellular systems and has been implicated in the pathogenesis of cancer. In the present study, we found that TLE1 is a regulator of anoikis in normal mammary epithelial and breast carcinoma cells. The induction of apoptosis following loss of cell attachment to the extracellular ...