stem cell based treatments are being increasingly explored for their possible potential to treat various cancers. mesenchymal stem cells believed to possess anti-tumor potential and are preferred for their properties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineage differentiation. this tumor tropism property of mscs could be utilized to del...

Background: Although significant advances have been made in the treatment of cancer, a significant number of patients with acute lymphoblastic leukemia (ALL) show resistance to treatment. Thus, it is necessary to seek novel therapeutic agents to overcome this problem. Studies have indicated that the expression level of mouse double minute 2 (MDM2), a negative regulator of p53, is markedly eleva...

To investigate the effect and molecular mechanism of vitexicarpin on biological behavior colorectal cancer cells is objective study. The human epithelial cell line Caco-2 were divided into control group, low, middle high dose groups vitexicarpin, plasmid cloning DNA-circ_0000419 DNA anti-microRNA-224 anti-microRNA-224-negative vitexicarpin+small interfering-circ_0000419 group vitexicarpin+micro...

background: there is accumulating evidence that a polyphenol present in olive oil, oleuropein, has antioxidant, anti-inflammatory and anti-apoptotic effects. this study aimed at determining the anti-apoptotic effect of oleuropein (ole) on dexamethasone-induced apoptosis of mouse thymocytes. method: mice were randomly divided to four groups as follow: dexamethasone (dex)-treated group (20 mg/kg;...

Abstract Objective Chondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), traditional Chinese medicine, possesses anti-inflammatory and anti-apoptotic properties chondrocytes. This study aimed to determine the protective of ASP on sodium nitroprusside (SNP)-induced chondrocyte apoptosis, explore underlying mechanism. Method Human pri...

Background: Brain is an organ that prone to oxidative stress and subsequent apoptosis due high aerobic metabolism relatively low antioxidants, especially under hyperglycemic condition. Cinnamomum burmanii (CB) a species abundant in Indonesia, therefore it of special concern for researchers identify the anti-apoptotic effect CB. Objective: This study was initiated determine CB extract on inhibit...

Human monocytic leukemia U937 cells readily undergo apoptosis when cells are treated with various stimuli including antitumor agents, tumor necrosis factor (TNF)-alpha and anti-Fas antibody. However, the signal transduction mechanism resulting in apoptosis is unclear. To study the mechanism of apoptosis, we isolated and characterized a mutant, UK110, from U937 cells, which was resistant to TNF-...

Conjugated linoleic acids (CLA) are distinctive polyunsaturated fatty acids. They present in food produced by ruminant animals and they accumulated seeds of certain plants. These naturally occurring substances have demonstrated to anti-carcinogenic activity. Their potential effect inhibit cancer has been shown vivo vitro studies. In this review, we the multiple effects CLA isomers on developmen...