objectives: this study sought to assess the effect of curcumin nanoparticles (curcnps) on antimicrobial property and shear bond strength (sbs) of orthodontic composite to bovine enamel. materials and methods: in this in vitro, experimental study, 1%, 5% and 10% curcnps were added to transbond xt composite. stainless steel brackets were bonded to 48 sound bovine incisors in four groups (n=12) us...

200 years ago the observation was already described that tumors sometimes shrink when cancer patients undergo bacterial infections. This is the basis for bacteria‐mediated cancer therapy an alternative therapeutic approach of growing interest. Several bacterial strains are able to colonize solid tumors after systemic administration; a few even induce tumor reduction. Apparently, the virulence o...

The increasing anti-bacterial drug resistance is one of the biggest challenges facing doctors around globe, so finding alternative treatments ideal options to overcome this problem. cruciferous family wealthiest plants worldwide because it contains most important secondary metabolites, glucosinolates, known for their anti-microbial properties. present study aimed evaluate effect glucosinolates ...

Defensin from a beetle, Allomyrina dichotoma, is known to have anti-bacterial activity against Gram-positive bacteria. This peptide, which comprises 43 amino acid residues, was effective against methicillin-resistant Staphylococcus aureus. We identified the active site of beetle defensin by measuring anti-bacterial activity against S. aureus of 64 overlapping 12-mer peptides with either a free ...

The concept of phage therapy to treat bacterial infections was born with the discovery of the bacteriophage almost a century ago. After a chequered history, its current renaissance is fueled by the dangerous appearance of antibiotic-resistant bacteria on a global scale. As a mark of this renewed interest, the unanswered problems of phage therapy are now being addressed, especially for human use...

A prototypical patient is presented to introduce important design issues for clinical trials of antibacterials in the treatment of ventilator-associated bacterial pneumonia.

New antibiotics with novel mechanisms of action are urgently needed to overcome the growing bacterial resistance problem faced by clinicians today. PC190723 and related compounds represent a promising new class of antibacterial compounds that target the essential bacterial cell division protein FtsZ. While this family of compounds exhibits potent antistaphylococcal activity, they have poor acti...

background: recently the role of platelets in the tissue regeneration, wound healing and prevention and control of infections has been reported. we aimed to assess the antimicrobial effect of human platelet concentrate against six bacteria, commonly found in wound and hospital-acquired infections. methods: in vitro susceptibility to samples of 10 random human platelet concentrates was determine...

objective(s):sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. the present investigation attempted to evaluate the potential of anti-cancer persian gulf sea cucumber species holothuria arenicola (h. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in ...

cuminum cyminum linn. (umbelliferae) is a plant, which has been used as a toothache remedy in folk medicine of iran. in this study, the potential anti-nociceptive and anti-inflammatory activities of the fruit essential oil of c. cyminum has been evaluated in chemical (formalin test) and thermal (tail-flick test) models of nociception and formalin model of acute inflammation in rats and mice. th...