The complement system plays an important role in the initial defense against Neisseria meningitidis. In contrast, uncontrolled activation in meningococcal sepsis contributes to the development of tissue damage and shock. In a novel human whole blood model of meningococcal sepsis, we studied the effect of complement inhibition on inflammation and bacterial killing. Monoclonal antibodies (mAbs) b...

Gastrointestinal (GI) diseases affect a large number of people all over the world. Uncontrolled acid secretion and occurrence of gastric ulcers are common disorders of GI tract which pose serious problems to human health. Many synthetic drugs have been used to treat GI disorders but a definite cure has not been discovered so far and the available medications cause several side effects. Nigella ...

Abstract As an alternative to antibiotics, nanoparticles are increasingly being employed target bacteria. Nanotechnology has the potential revolutionize treatment of bacterial infections. Biosynthesis is becoming popular as a cutting-edge method for producing functionally diverse Nanoparticles with enormous therapeutic potential. Various biological resources have already proven their ability ma...

the series of 3-(substitutedphenyl)-n-(4h-1,2,4-triazol-4-yl)acrylamide compounds were prepared byreaction of 4-amino-1,2,4-triazole with acetyl chloride followed by claisen-schmidt condensation reactionwith different aromatic aldehydes. the structures of new compounds were confirmed by ir, 1h-nmr and13c-nmr spectral data. anti-bacterial and anti-fungal activities were evaluated and compared wi...

Elliott, Susan N., J. L. Wallace, W. McKnight, D. G. Gall, J. A. Hardin, M. Olson, and A. Buret. Bacterial colonization and healing of gastric ulcers: the effects of epidermal growth factor. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G105–G112, 2000.—Experimental gastric ulcers are rapidly colonized by various bacteria, resulting in significantly impaired healing. Epidermal growth factor...

Objective(s): Chitosan based composite fine fibers were successfully produced via a centrifugal spinning technology. This study evaluates the ability of the composites to function as scaffolds for cell growth while maintaining an antibacterial activity. Materials and methods: Two sets of chitosan fiber composites were prepared, one filled with anti-microbial silver nanoparticles and another on...

calendula of.cinalis (asteraceae) is widely used in traditional medicine as an anti-in.ammatory agent and has also been reported to have anti-bacterial, anti-fungal and anti-viral activities.  sesquiterpene glycosides, saponins, triol, triterpenes and .avonoids are observed in its composition. the present study was designed to evaluate the antinociceptive effect of hydro-alcoholic extract of ca...

conclusions shiitake essential oil is an effective anti-bacterial and anti-biofilm agent on important oral pathogens and has a possible therapeutic potential as an oral anti-biofilm agent. results no inhibitory effect was observed on f. nucleatum biofilms (p > 0.05). significant disruptive properties on a. actinomycetemcomitans at values lower than the mic (3.90 µg/ml) was detected (p < 0.05). ...

BACKGROUND Natural compounds with anti-microbial properties are attractive reagents to reduce the use of conventional antibiotics. Carvacrol, the main constituent of oregano oil, inhibits the growth of a variety of bacterial foodborne pathogens. As concentrations of carvacrol may vary in vivo or when used in animal feed, we here investigated the effect of subinhibitory concentrations of the com...