Background: Heracleum persicum (H. persicum) is a medicinal herb used in Iranian traditional medicine for its anti-toxic property. It is commonly consumed in the form of food additives and as a medicinal herbal tonic to treat liver and kidney diseases. The present study aimed to investigate the anti-oxidant, anti-diabetic, and anti-hyperlipidemic effects of H. persicum hydroalcoholic extract in...

OBJECTIVE a strong association has been observed between celiac disease, generally its silent clinical form, and autoimmune disorders. A potential correlation with inflammatory bowel disease has also been suggested. Anti-tissue transglutaminase antibodies have been detected in Crohn´s disease. We investigated the prevalence of celiac disease in patients with autoimmune diabetes and in Crohn´s d...

TGF-β1 upregulates microRNA-192 (miR-192) in cultured glomerular mesangial cells and in glomeruli from diabetic mice. miR-192 not only increases collagen expression by targeting the E-box repressors Zeb1/2 but also modulates other renal miRNAs, suggesting that it may be a therapeutic target for diabetic nephropathy. We evaluated the efficacy of a locked nucleic acid (LNA)-modified inhibitor of ...

Kovai Kizhangu Choornam has been widely used in Siddha system of medicine for diabetes. The powder (Kovai Kizhangu Choornam) showed a significant inhibitory effect was screened at 500 mg/kg, for the in vivo anti-diabetic activity on alloxan induced diabetic rats. Glibenclamide: Metformin (0.5:40mg/kg) used as reference standard. Single dose (400 mg/kg) treatment with the siddha drug Kovai Kizha...

Rats can be made diabetic by pancreatectomy (Scow, 1957) or by the administration of alloxan (Lukens, 1948) or of anti-insulin serum (Armin, Grant & Wright, 1960b). Some of the metabolic abnormalities in pancreatectomized (Scow & Chernick, 1960) and alloxan-diabetic (Lukens, 1948; Spiro & Hastings, 1958) rats have been studied, but little is known about the serum-treated animals. The observatio...

OBJECTIVE To examine whether a history of periodontitis (PD) before anti-diabetic treatment is associated with risk of rheumatoid arthritis (RA) development in newly-treated diabetes mellitus (DM) patients. METHODS We conducted a population-based retrospective cohort study using the 1997-2009 National Health Insurance (NHI) claims data of one million representative individuals from all NHI en...

background & aim: diabetes mellitus in long-term through various means such as augmented oxidative stress is associated with disturbances such as pain and cognition in humans and laboratory animals. according to the evidence of anti-diabetic extract of biarum bovei (bb), effect of oral administration of this extract was evaluated on blood glucose level and pain threshold in diabetic rats. e...