CONTEXT Despite the availability of efficacious anti-diabetic drugs, which act by different mechanisms to reduce the blood-glucose, the majority of people with diabetes on anti-diabetic drug therapy, have poor glycemic control and diabetic vascular complications. AIM AND OBJECTIVES The aim was to study the prescribing pattern and efficacy of anti-diabetic drugs in maintaining optimal glycemic...

Background: Type 2 diabetes mellitus with hyperlipidemia is a common disease. Conventional anti-hyperglycemic and anti-hyperlipidemic drugs have limited efficacies and important side effects, so that alternative agents are needed. Previous studies suggest that fiber-free artichoke (Cynara scolymus L.) leaf extract may have anti-hyperglycemic and anti-hypercholesterolemic effects in hypercholest...

diabetes is a common metabolic disease in the world that has many adverse effects. olibanum gum resin (from trees of the genus boswellia) has traditionally been used in the treatment of various diseases such as diabetes. the aim of this study was the comparison of olibanum gum resin effect with placebo on the treatment of type 2 diabetes. inclusion criteria was diabetic patients with fasting bl...

The disease burden of diabetes mellitus is increasing throughout the world. The need for more potent drugs to complement the present anti-diabetic drugs has become an imperative. Astragalus membranaceus, a key component of most Chinese herbal anti-diabetic formulas, has been an important prospect for lead anti-diabetic compounds. It has been progressively studied for its anti-diabetic propertie...

In management of diabetes, glucose lowering is the basic target treatment. Insulin essential to type 1 diabetes. Non-insulin therapy in 2 diabetes very diverse and continuously developing improve control prevent diabetes-related complications. recent 30 years, recommended specifications anti-diabetic drugs are high glucose-lowering efficacy, low risk hypoglycemia, less burden weight gain, cardi...

Aim: To evaluate the effect of Enalapril on blood glucose level in normal rats and interaction with the oral anti-diabetic drugs in Alloxan-induced diabetic rats. Method: The rats were classified into nine groups (n = 6).The Group I –II were normal and Group III –IX were diabetic. The experimental diabetes in rats was induced by intra-peritoneal injection of Alloxan monohydrate (135 mg/kg body ...

Introduction: Diabetic endothelial dysfunction is accompanied by increased oxidative stress and upregulated proinflammatory inflammatory mediators in the vasculature. Activation of peroxisome proliferator-activated receptor-alpha (PPAR-α) results antioxidant anti-inflammatory effects. Aim this study to investigate effect fenofibrate, a PPAR-α activator, on stress, inflammation its anti-oxidant ...

Dyslipideamia is a major cause, observed in type 2 diabetic subjects with micro vascular complications and membrane functional alteration is very common. The relative amount of phospholipids and cholesterol is responsible entity for normal function and membrane fluidity and rigidity. Many research studies reported on plasma lipid anomaly even on anti diabetic agents and also our earlier laborat...

Background: There is a direct correlation between ocular vascular endothelial growth factor (VEGF) level and progression of pathological outcomes in diabetic retinopathy. In our previous study, the periocular administration of propranolol and celecoxib could significantly reduce ocular VEGF levels in a diabetic mouse model. Here, we investigated the changes of serum VEGF after ...

OBJECTIVE Type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (ATD). Genetic susceptibility to autoantibody formation in association with ATD and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about the situation in the Chinese population. We have, therefore, investigated the prevalence of anti-thyroid peroxidase (an...