Benign familial infantile convulsions (BFIC) is a recently identified partial epilepsy syndrome with onset between 3 and 12 months of age. We describe the clinical characteristics and outcome of 43 patients with BFIC from six Dutch families and one Dutch-Canadian family and the encountered difficulties in classifying the syndrome. Four families had a pure BFIC phenotype; in two families BFIC wa...

For many neurologists, being called upon at an unsocial hour to give immediate advice on anti-epileptic therapy is not an uncommon scenario. It is therefore vital to have rapid access to reliable, practical and up-to-date information on anti-epileptic agents. The newly revised Epilepsy Prescriber’s Guide to Antiepileptic Drugs provides the ideal, pocket-sized reference guide, covering all anti-...

PURPOSE Human photosensitive epilepsy models have been used as proof of principle (POP) trials for epilepsy. Photosensitive patients are exposed to intermittent photic stimulation and the reduction in sensitivity to the number of standard visual stimulation frequencies is used as an endpoint. The aim of this research was to quantify the predictive capabilities of photosensitive POP trials, thro...

Drugs can influence cognitive function in several different ways. The cognitive enhancers or nootropics have become a major issue in drug development during the last decade. Nootropics are defined as drugs that generally increase neuron metabolic activity, improve cognitive and vigilance level and are said to have antidementia effect (1). These drugs are essential for the treatment of geriatric...

Abstract Background Migraine and epilepsy are both episodic disorders, with some overlapping symptoms, mechanisms therapies. Clinically, there is a comorbid relationship between them. Some migraine patients may exhibit epileptic discharges by electroencephalogram (EEG) recording. Therefore, the two conditions easily misdiagnosed. Case presentation We reported 16-year-old female patient who was ...

background and objective: epilepsy is a common disease in communities. since there is no cure for it and current treatments are not effective for every patient, new method for medical treatment of epileptic patients is necessary. as nmda receptors antagonists are the most prominent anti-epileptic drugs, in this study we synthesized and investigated anti-epileptic effect of a new piperidine deri...

This review reports on the past, current and potential future developments in aspects of the ketogenic diet in epilepsy treatment for children who have refractory epilepsy (uncontrolled seizures after having tried at least two anti-epileptic drugs). The ketogenic diet is based on putting the body into ketosis, so that is uses ketones rather than glucose for the energy in the brain. The diet com...

introduction: transforming growth factor-beta 1 (tgf-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of ischemic stroke (is), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509c/t tgf-β1 gene polymorphism has been found to be assoc...

This article deals with the clinical profile of children with cerebral palsy and epilepsy, and to study the clinical predictors of response to anti-epileptic drugs. It is a prospective hospital based follow-up study. All the children who presented with cerebral palsy and history of seizure (other than neonatal seizures) over a period of one year were included. Seizures were classified according...

PURPOSE Epilepsy has an impact on the reproductive system. Males with epilepsy have lower fertility rates, hypo-sexuality and reduced potency compared with the general population. Anti-epileptic drugs and epilepsy itself are thought to be responsible for this reduced fertility. LEV is a second-generation anti-epileptic agent with low incidences of both adverse effects and drug-drug interactions...