Objective: To investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among Iranian patients before and after sodium valproate treatment.   Patients and Methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic epilepsy were recruited. Serum antinuclear antibodies (ANA), anti-cardiolipin antibodies (aCL), a...

Background Neuronal L-type voltage-gated calcium channels (LTCCs) were shown to be involved in the control of neuronal excitability, synaptic plasticity and gene expression. These mechanisms are altered in epileptic tissue and are thought to contribute to epileptogenesis. Hence, LTCCs are interesting targets for epileptic and anti-epileptic therapy. However, their role in epilepsy, whether LTCC...

Introduction Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized epileptic syndrome, mostly initiated before adolescence. It is usually preceded by myoclonic jerks (sudden brief involuntary muscle spasm) in the second decade of life. JME may be presented with different types of seizure activity. Simple bilateral myoclonic seizure is the most seen clinical presentation of...

Sulphonamides are the first effective chemotherapeutic agents used for bacterial infection in humans. Sulfonamides have a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, anti retroviral, anti cancer, antiinflammatory, and used as diuretic. This review consists of a discussion on the...

Paroxysmal kinesiogenic choreoathetosis is rare movement disorder, which is frequently misdiagnosed as an epileptic disorder partly because of a good response to anti-epileptic drugs (Phenytoin sodium). At times these patients are mistaken for a conversion reaction. One such case is described.