INTRODUCTION Fungal sepsis is an increasingly common problem in intensive care unit patients.Mortality from fungal sepsis remains high despite antimicrobial therapy that is highly active against most fungal pathogens, a finding consistent with defective host immunity that is present in many patients with disseminated fungemia.One recently recognized immunologic defect that occurs in patients wi...

Filamentous fungi are a common cause of blindness and visual impairment worldwide. Using both murine model systems and in vitro human neutrophils, we found that NADPH oxidase produced by neutrophils was essential to control the growth of Aspergillus and Fusarium fungi in the cornea. We demonstrated that neutrophil oxidant production and antifungal activity are dependent on CD18, but not on the ...

While Pneumocystis pneumonia (PcP) still impacts the AIDS patients, it has a growing importance in immunosuppressed HIV-negative patients. To determine the anti-Pneumocystis therapeutic efficacy of new compounds, animal and in vitro models have been developed. Indeed, well-designed mouse or rat experimental models of pneumocystosis can be used to describe the in vivo anti-Pneumocystis activity ...

echinoderms are independent and quite special branch of world animals. sea cucumbers are among the strangest members of echinoderm class regarding their structure and physiology. these fauna have been tested with regard to anti-bacterial, anti-fungal, anti-coagulants, anti-virus, cytotoxic, hemolytic and anti-hiv features. in this study, the antibacterial activity of holothuria leucospilota sea...

Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range of biological activity, including anti-fungal, anti-viral and anti-cancer effects. Our previous studies have demonstrated the potent in vivo anti-tumor activity of novel TSCs and their ability to overcome resistance to clinically used chemotherapeutics. In the current study, 35 novel TSCs of 6 different clas...

background: gallic acid (ga) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti‑inflammatory, anti‑cancer, and anti‑fungal properties. the aim of this study was to assess the protective effect of ga on cyclophosphamide (cpa)‑induced hepatotoxicity in male wistar rats. methods: sixty rats were grouped into six groups of 10 rats per group. group 1 recei...

The aim of the present study was to investigate anti fungal activities of the fresh extract of Allium ascalonicum Linn. (Liliaceae) against clinically important yeast, dermatophytes and some saprophytic fungi in vitro. The anti fungal effects of fresh crude juice of shallot were determined against 11 isolates of Candida albicans, three species of dermatophytes (Microsporum gypseum, Trichophyton...