Background: Early recognition of neonatal seizures secondary to pathogenic variants in potassium or sodium channel coding genes is crucial, as these are often resistant commonly used anti-seizure medications, but respond well sodium-channel blockers. We report a unique aEEG pattern caused by SCN2A and KCNQ3 variants, adding regular EEG description. Methods: International multicentre descriptive...

Introduction: Epilepsy is a common central nervous system (CNS) disorder characterized by seizures resulting from episodic neuronal discharges. The incidence of toxicity and refractoriness has compromised the clinical efficacy of the drugs currently used for the treatment of convulsions. Thus, there is a need to search for new medicines from plant origin that are readily available and safer for...

Maturation of neural circuits requires activity-dependent processes that underpin the emergence of appropriate behavior in the adult. It has been proposed that disruption of these events, during specific critical periods when they exert maximal influence, may lead to neurodevelopmental diseases, including epilepsy. However, complexity of neurocircuitry, coupled with the lack of information on n...

Background: Epilepsy is a chronic disease characterized by the occurrence of recurrent non provoked epileptic seizures. This condition affects quality life those affected as well their caregivers’ not only itself but also because comorbidity. It requires daily care and continuous use anti seizure medication at specific times day.

Lacosamide has been reported to have been successfully used for non-convulsive status epilepticus after benzodiazepine failure, and convulsive status epilepticus after benzodiazepine and levetiracetam failure. We report a case of simple motor status epilepticus refractory to benzodiazepines and multiple anti-epileptic medications (AEDs) over 4 days. The addition of lacosamide in combination wit...

Background: Poisoning with non-barbiturate anti-epileptics (carbamazepine, sodium valproate and phenytoin) shows a growing trend. The objective of this study was to investigate clinical manifestations of poisoned patients with these medications. Methods: This prospective study was conducted in the Shiraz Shoushtari Hospital during a two-year period from 2010 to 2012. Poisoning was confirmed acc...

introduction: refractory status epilepticus is a life-threatening disease in children wherein seizure movements don't response to first line anti convulsion drugs. this study reviewed risk factors, management and early outcome of children with refractory status epilepticus. methods: patients with refractory status epilepticus admitted in tabriz children's hospital between 2003 and 200...

First epileptic seizure is a common reason for attending the emergency department. Its management is focused on diagnosis of the episode and on identification and treatment of the underlying cause. Occasionally, anti-epileptic treatment will be required. However, when the seizure is prolonged - a condition known as status epilepticus - it becomes a life-threatening process and requires immediat...

Cerebral cavernous malformations (CCMs) are angiographically occult and consist of a honeycomb-like, low-pressure bed of ectatic vasculature with no intervening neural tissue. Although most cases are sporadic, there are several familial forms. A hemosiderin rim frequently exists from repeated microhemorrhage, leading to reactive cortical gliosis. Because there are no neurons within a cavernous ...