Background: Despite introduction of modern antiepileptic drugs, 30% of epileptic patients are still drug resistant. Remarkable three-dimensional spatial structure of AdCA, yet the simplicity of the molecule, makes AdCA a promising lead compound. Methods: Sedative/motor impairment and 24-h mortality rate of AdCA were determined in mice. Impact of AdCA on (1) threshold and occurrence of clonic se...

Mitochondrial dysfunction mainly affects organs with high metabolic demand, primarily the brain. Epilepsy is a common phenotypic sign of both syndromic and non-syndromic mitochondrial diseases. in diseases poorly treatable often an unfavorable prognostic sign. Patients epilepsy are prescribed various anti-seizure medications. Mitochondriotoxic drugs should be avoided. Descriptions MELAS-syndrom...

The goal of this study was to elucidate the anti-convulsion mechanisms of ear-point stimulation in rat with experimental seizure. We prepared the epilepsy rats by intrahippocampal injection of penicillin. One hour later the lower 1/2 auricular lobules of seizure rats, containing ear-points Pizhixia and Shenmen etc., was electrically stimulated, which was imitated as ear-point electrical acupunc...

objective: regarding the anticonvulsant effects of satureja hortensis (s. hortensis) in avicenna’s book: canon of medicine; the present study was undertaken to evaluate the anti- eplileptic effects of s. hortensis aqueous and ethanolic aerial part extracts. furthermore, the mechanisms of their anticonvulsant activities were also evaluated. materials and methods: seizure was induced by pentylent...

Background Eslicarbazepine acetate (ESL) is a third-generation anti-seizure drug used in patients with focal-onset seizures. This retrospective study aimed to evaluate the efficacy and safety of ESL for treatment epilepsy real-world clinical setting. Methods From March 2022 April 2023, medical records who were prescribed at Gyeongsang National University Changwon Hospital analyzed. Efficacy out...

PURPOSE Levetiracetam (LEV) therapeutic range (20-40mg/L) and potential drug interactions were assessed in people with epilepsy (PWE). METHOD Fifty-two PWE had LEV and concomitant medications [carbamazepine (CBZ); valproate (VPA); lamotrigine (LTG)] blood levels measured and compared to seizure activity. Lacosamide (LCM) levels were unavailable. Adopted therapeutic ranges were: 20-40mg/L - LE...

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The generalized differential quadrature (GDQ) method is used to obtain the computational results of two-layer cross-ply laminated shell under rapid uniform heat induced vibration. In the thermally insulated vibration analyses of a laminated shell, the sudden uniform heat input over its lower surface only and temperature load is linear of axial coordinate. The GDQ method provides a method for ca...

Purpose: In the acute phase of Cerebral Venous Sinus Thrombosis (CVST), approximately 35-50 % patients diagnosed epileptic seizures. This study aimed to investigate demographic and clinical characteristics, frequency seizures, prognosis during a one-year follow-up period.
 Materials Methods: The files who were followed up with diagnosis ischemic stroke between January 1, 2018 2022 evaluate...

OBJECTIVE To discriminate seizures from interictal dynamics based on multivariate synchrony measures, and to identify dynamics of a pre-seizure state. METHODS A linear discriminator was constructed from two different measures of synchronization: cross-correlation and phase synchronization. We applied this discriminator to a sequence of seizures recorded from the intracranial EEG of a patient ...