The effects of the addition of Vigabatrin, a new anti-epileptic drug, to the therapy of 128 patients with severe medically refractory epilepsy is reported. Forty two (33%) of patients experienced side effects, which were predominantly neurotropic. In 28 (22%), the drug was withdrawn because of these side effects. The commonest side effects were drowsiness and behavioural change. The remaining 1...

how to cite this article: fallah r, tirandazi f, ferdosian f, fadavi n. iron deficiency and iron deficiency anemia in children with first attack of seizure and on healthy control group : a comparative study. iran j child neurol. 2014 summer;8(3): 18-23.   abstract objective seizures are the most common pediatric neurologic problem. research of the association between iron deficiency and seizure...

BACKGROUND Explosive synaptogenesis and synaptic pruning occur in the hippocampus during the first two weeks of postnatal life, coincident with a heightened susceptibility to seizures in rodents. To determine the temporal correlation between microglial development and age-dependent susceptibility and response to seizures, we quantified developmental changes in basal microglia levels and seizure...

INTRODUCTION Pregabalin efficacy and safety as an adjunctive treatment for partial seizures was evaluated using an open-label, flexible-dose. STUDY DESIGN In 98 adults with refractory partial epilepsy taking 1-3 anti-epileptic drugs with ≥2 seizures during an 8-week baseline period. METHODS Pregabalin was increased to ≤600 mg/day during a 9-week dose optimization period with dosage maintain...

Temporal lobe epilepsy (TLE) is the most common form of drug resistant epilepsy. Current treatment is symptomatic, suppressing seizures, but has no disease modifying effect on epileptogenesis. We examined the effects of Z944, a potent T-type calcium channel antagonist, as an anti-seizure agent and against the progression of kindling in the amygdala kindling model of TLE. The anti-seizure effica...

PURPOSE The role of EEG after a first seizure has been debated. Epileptiform EEG activity is a good predictor of seizure recurrence, but is reported in only 8-50% of first-seizure adult patients. Even if the EEG is abnormal, the opinions about treatment after a first seizure differ. The role of EEG in treatment decisions after remission or recurrence is also unclear. This study aims to identify...

BACKGROUND Epilepsy is a chief communal health problem. Antiepileptic drugs only provide symptomatic treatment. Walnut Kernels (WK) have high concentrations of phenolic compounds, which have beneficial effects on human health because of their antioxidant and anti-atherogenic properties. The present study was designed to evaluate the efficacy of WK supplementation for the prevention of experimen...

.........................................................................................................................xi I. GENERAL INTRODUCTION .........................................................................................1 A. Epilepsy ................................................................................................................1 B. Current treatments of epileps...

Rasmussen encephalitis (RE), initially described half a century ago, is an inflammatory unihemispheric brain disorder. Its two clinical key facets are the progressive tissue and function loss and the epilepsy, often in form of epilepsia partialis continua. For both, treatment options are available. Anti-seizure effect of anti-epilepsy drugs is usually limited to secondarily generalized seizures...

Epilepsy is one of the most occurring neurological diseases. The main characteristic this disease a frequent seizure, which an electrical imbalance in brain. It generally accompanied by shaking body parts and even leads (fainting). In past few years, many treatments have come up. These mainly involve use anti-seizure drugs for controlling seizures. But 70% cases, these are not effective, surger...