introduction: olive leaf contains anti-inflammatory and cox-2 inhibitor compounds. considering the role of the cox enzyme in seizures, this research was performed to assess the effects of this extract in treatment of seizures induced by ptz. methods: in this research, male wistar rats (200±20 g) were injected intra-cerebroventricularly with 1 μl saline or olive leaf extract (125 μg, 250 μg and ...

The current regimen for treating nerve agent poisoning does not sufficiently suppress the excitotoxic activity that causes severe brain damage, especially in cases where treatment is delayed and nerve agent-induced status epilepticus develops. New therapeutic targets are required to improve survivability and minimize neuropathology after irreversible acetylcholinesterase inactivation. Earlier s...

Adenosine has long been considered an endogenous anti-epileptic compound. This concept was based on the widespread distribution of adenosine A1 receptors (A1R), which are mostly located in excitatory synapses; here, A1R inhibit glutamate release, decrease glutamatergic responsiveness and hyperpolarise neurons. However, the combined observation that synaptic A1R undergo desensitisation in chroni...

Epilepsy is a neurological disease of the central nervous system. It is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. In the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the dis...

ObjectivesTo investigate the clinical characteristics, final diagnosis, investigation results, management, response to anti-seizure medications (ASMs) and outcomes of individuals assessed in a First Seizure service over 5-year period.MethodsRetrospective analysis 772 who were clinically dedicated at National Hospital for Neurology & Neurosurgery (NHNN), Queen Square period.Results772 following ...

The availability of zebrafish larvae model of epileptic seizure provides opportunities to identify novel anticonvulsants for treatment of people with epilepsy. However, the major parameters of zebrafish behavior assay for assessing anti-epileptic drug efficacy existed disparity, which resulted in different results in previous studies. In this study, we chose the high, medium, slow-speed moved d...

Vagus nerve stimulation (VNS) is generally considered as a palliative treatment for patients with drug-resistant partial onset epilepsy. Although seizure freedom can be occasionally achieved in patients with VNS, anti-epileptic medications (AEDs) are commonly required to maintain seizure freedom. We report a case that a patient became seizure free for 5 years with VNS monotherapy. To our knowle...

Case presentation: Three-years-old male attended with a generalized tonic-clonic seizure. No history of traumatic brain injury, fever or associated flu-like symptoms. Days before, aggressive behavior, slurred speech, visual hallucination. Only one previous seizure, month ago, without status epilepticus. Electroencephalogram (EEG): brush pattern extreme delta, cerebrospinal fluid (CSF) IgG+ for ...

In this study, we focused on the neuro-behavioral profile, toxicity, and ‎possible mechanisms of action of ‎ Dorema ammoniacum gum essential oil (DAG-EO). For this purpose, passive avoidance and Y-maze tests were performed to evaluate the potential effect ‎of DAG-EO in the attenuation of memory impairment induced by 49 days administration of D-‎galactose and acute injection of scopolam...