The major hemorrhagin from C. purpureomaculatus (mangrove pit viper) venom was purified to homogeneity and termed Maculatoxin. Maculatoxin has a molecular weight of 38 kDa as determined by SDS-PAGE. It is an acidic protein (pI= 4.2) and exhibited proteolytic and hemorrhagic activities (MHD10 = 0.84 microg in mice) but was not lethal to mice at a dose of 1 microg/g. The hemorrhagic activity of M...

  All desalination methods which are currently used have limitations. A newly designed instrument by Zare A.M. was tested and compared with currently used method in Razi Vaccine and Serum Research Institute(RVSRI). Samples of anti snake venom for desalination was provided by department of anti-serum, RVSRI. Parameters included in this study were time and water consumption during desalination pr...

Phospholipases type A2 (PLA2s) are the most abundant proteins found in Viperidae snake venom. They are quite fascinating from both a biological and structural point of view. Despite similarity in their structures and common catalytic properties, they exhibit a wide spectrum of pharmacological activities. Besides being hydrolases, secreted phospholipases A2 (sPLA2) are an important group of toxi...

Snake venoms are known to cause different metabolic disorders, altering cellular and enzymatic activities in animals and releasing pharmacological substances. The objective of this study is to explore the effect of the lethal dose of Indian cobra (Naja naja) venom snake on the lung tissue of albino rats. The rats were divided into three groups, the first group served as a control group, while t...

Disintegrins have been previously described in the venom of several snake families inhibiting signal transduction, cell-cell interactions, and cell-matrix interactions and may have therapeutic potential in heart attacks, thrombotic diseases, and cancers. This investigation describes the first disintegrin isolated from South American Crotalus venom (Venezuelan rattlesnake Crotalus durissus cuman...

Background:Envenomation by Macrovipera lebetina (M. lebetina) is characterized by prominent local tissue damage, hemorrhage, abnormalities in the blood coagulation system, necrosis, and edema. However, the main cause of death after a bite by M. lebetina has been attributed to acute renal failure (ARF). It is unclear whether the venom components have a direct or indirect action in causing ARF. T...

The species Kalanchoe brasiliensis and Kalanchoe pinnata, both known popularly as "Saião," are used interchangeably in traditional medicine for their antiophidic properties. Studies evaluating the anti-venom activity of these species are scarce. This study aims to characterize the chemical constituents and evaluate the inhibitory effects of hydroethanolic leaf extracts of K. brasiliensis and K....

Background: Snakes have always attracted scientists and it caused awe fear because of the harmful strength its toxins components various from one snake to another. In 2017, World Health Organization (WHO) listed venom as a neglected high-priority disease, with snakes causing up 2.7 million venomous bites, nearly 100,000 victims, three times number human disabilities. Objective: i- Snake backgro...