background: thiamine (vitb1) is a vitamin with various important physiological functions and postulated therapeutic effects.  its use as an analgesic in neuropathic pain has been undergoing in clinical settings. however, there has been little experimental investigation on this effect. in this study, anti-nociceptive and anti-inflammatory effects of thiamine were investigated in mice. methods: t...

objective: triptolide, the active component of tripterygium wilfordii hook f has been used to treat autoimmune and inflammatory conditions for over two hundred years in traditional chinese medicine. however, the processes through which triptolide exerts immunosuppression and anti-inflammation are not understood well. in this review, we discuss the autoimmune disorders and inflammatory condition...

tetracyclines are broad spectrum antibiotics which are inexpensive and widely available and have an appropriate safety profile. in addition to antibiotical effects, tetracyclines can inhibit matrix metaloproteinase and collagenase, and subsequently reduce inflammation, angiogenesis, and neovascularization. they have partial neuro-protective, anti-apoptotic and antioxidant properties. given thes...

one of the most common health problems are diseases of the cardiovascular system with a great bulk of disease burden; while a considerable number of cardiac patients undergo cardiac surgery; cardiac surgical procedures with cardiopulmonary bypass (cpb) are nowadays among the top list of surgical procedures. more than half of a century has passed since the introduction of total cardiopulmonary b...

cyclizine (1-benzhydryl-4-methyl-piperazine, cas 82-92-8, cyc, i), a piperazine derivative, belongs to h1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other h1-receptor antagonists. in this study, two new tolyl and cumene derivatives of i (1-ethyl-4-[(p-isopropylphenyl) (p-tolyl) methyl]-piperaz...

Background and objectives: Apium graveolens L. (celery) has been considered as sedative, analgesic, carminative, antispasmodic and diuretic plant in traditional Iranian medicine. The aim of the present study was to evaluate the anti-nociceptive and anti-inflammatory effect of celery root in mice. Methods: Analgesic effect of celery root was de...

Neuro-inflammation is the inflammation of nervous tissue due to oxidative stress, aging and autoimmunity and the major cause of Alzheimer's, Parkinson's and Huntington's disease. Periodontitis, the inflammation of the gums and supporting structures of the teeth, is a chronic peripheral immuno-inflammatory condition, affiliated with gram- negative, anaerobic bacteria that cause low-grade systemi...

Canarium L. is used in folk medicine as anti-inflammatory, antibacterial, antifungal, antitumor, heptoprotective, antioxidant, and anti diabetic properties. The present study investigeated the invivo anti-inflammatory activity of  essential oil obtained by hydrodistillation of resin of Canarium strictum Roxb. In the current study, anti-inflammatory activity of essential oil of...

canarium l. is used in folk medicine as anti-inflammatory, antibacterial, antifungal, antitumor, heptoprotective, antioxidant, and anti diabetic properties. the present study investigeated the invivo anti-inflammatory activity of  essential oil obtained by hydrodistillation of resin of canarium strictum roxb. in the current study, anti-inflammatory activity of essential oil of canarium strictum...

Neuro-inflammation, biochemical and cellular responses of the nervous system to injury, infection or neurodegenerative diseases, is a major risk factor for Alzheimer's, Parkinson's and Multiple Sclerosis. Periodontitis is a serious bacterial gum infection that damages the soft tissue and teeth supporting bones, causing teeth loss. It also renders systemic inflammation by secretion of pro-inflam...