background & aim: allium sativum commonly known as garlic is an herb used over years to prevent from various ailments such as cardiovascular diseases, cognitive disorders and also enhances the immune system. the aim of the present study is to study the in vitro antiarthritic and antihemolytic potential of garlic in aqueous and methanolic extracts. fourier transform infrared spectroscopy was per...

Institute of Experimental and Clinical Medicine of Vilnius University, Vilnius, Lithuania Background: The inclusion of immunomodulators into the schemes of the treatment of autoimmune process, especially under the therapy with immunosuppressive preparations, is motivated because immunological disturbances play an essential role in the pathogenesis of these conditions. The aim of the present stu...

INTRODUCTION The objective of this study was to determine the anti-inflammatory, nociceptive, and antiarthritic effects of piperine, the active phenolic component in black pepper extract. METHODS The in vitro anti-inflammatory activity of piperine was tested on interleukin 1beta (IL1beta)-stimulated fibroblast-like synoviocytes derived form patients with rheumatoid arthritis. The levels of IL...

Cynodon dactylon (L.) (Poaceae) is traditionally used herb to treat fevers, skin diseases and rheumatic affections. The ethanolic extract of C. dactylon was found to be safe at all the dose levels (100, 200 and 400 mg/kg, orally) and there was no mortality up to the dose of 5000 mg/kg of extract when administered orally. C. dactylon showed significant antiarthritic activity against Freund's com...

Background & Aim: Allium sativum commonly known as garlic is an herb used over years to prevent from various ailments such as cardiovascular diseases, cognitive disorders and also enhances the immune system. The aim of the present study is to study the in vitro antiarthritic and antihemolytic potential of garlic in aqueous and methanolic extracts. Fourier tran...

Gold(Ill) is isoelectronic (5d8) and often isostructuml (square-planar) with Pt(ll) and might form the basis of active anticancer agents [1]. However little is known about the biochemistry of Au(lll), a subject also of interest in connection with the side-effects of antiarthritic gold drugs [2]. In this work we have explored the binding of [Au(lll)(diethylenetriamine)CI]CI2 to tripeptides over ...

The antiarthritic drug, aumnofin ("Ridaura’) is an orally-active antiarthdtic drug containing linear Au(I). The gold is co-ordinated by triethylphosphine and the sulfur of tetraacetyl-I-D-1thioglucose (HSATg). Deacetylation occurs during absorption and then the thioglucose is displaced via ligand displacement reactions. Over 80% of the gold in the blood is carded by serum albumin, a 66 kDa sing...