A new genetic study has shown that the phagocytic ability of Drosophila blood cells, the hemocytes, may be important for the further induction of an antibacterial response in other tissues.

This study assessed the functional importance of residues located at the i(-2) position of face 4 of the tandem repeat loops of the quinolone resistance protein QnrVC7 through mutagenesis studies. The i(-2) position of face 4 on different coils required residues with different natures. Some substitutions reduced the protective activity of QnrVC7, while some of them increased it. These findings ...

Pseudomonas Quinolone Signal Modulates Cystic Fibrosis Epithelial Cell Response through the TollLike Receptor 4 Patricia R. Wardwell1,2, David R. Wilson1,2, Dewayne L. Garner1,2 and Rebecca A. Bader1,2* 1Department of Biomedical & Chemical Engineering, Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY, USA 2Onondaga Community College, Syracuse, NY, USA SOJ Immunology Open Acces...

A preliminary study was made on the antibacterial mechanism of copper-bearing antibacterial stainless steels against E.coli through experiments of microbiology such as EDTA (ethylenediaminetetraacetic acid) complexing, DNA smearing and AFM (atomic force microscope) observation. It was measured that the antibacterial stainless steels showed excellent antibacterial functions with antibacterial ra...

A novel antibacterial glass-ionomer cement has been developed. Compressive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the formed cement. Compressive yield strength (YS), modulus (M), diametral tensile strength (DTS) and flexural strength (FS) were also determined. All the formulated antibacterial cements showed a significant...

In order to develop an self-cured acrylic resin having an antibacterial property, three types of commercially available inorganic antibacterial agents were added, at 1% each, to UNIFAST III to evaluate the antibacterial property. The antibacterial test evaluated the amount of Streptococcus mutans attached to UNIFAST III, the residual viable count of Streptococcus mutans cultured on UNIFAST III....

Some antibacterial agents have been shown to neutralize the biological properties of bacterial lipopolysaccharide (LPS). The aim of this study was to elucidate the role of gentamicin, tobramycin, imipenem, tigecycline, and isoniazid in affecting the production of nitric oxide (NO) induced by LPS in mice. Groups of mice were injected intraperitoneally with LPS alone, antibacterial agent alone, o...

BACKGROUND Antibacterial drug use is a major risk factor for bacterial resistance, but little is known about antibacterial use in US hospitals. The objectives of this study were to characterize trends in antibacterial use in a sample of US hospitals and to identify predictors of use. METHODS We measured systemic antibacterial use from validated claims data at 22 university teaching hospitals ...

In the present research work three Pakistani medicinal plants were scrutinized for their antibacterial and phytotoxic potentials. The antibacterial and phytotoxic effects were determined for the crude methanolic extract and its subsequent solvent fractions. In case of antibacterial effect the chloroform and ethyl acetate fractions of all tested plants showed moderate antibacterial potential. Al...

In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremi...