sepsis constitutes an important cause of hospital admission with a high mortality rate. appropriate antibiotic therapy is the cornerstone of therapy in patients with sepsis. although numerous studies have recommended early antibiotic initiation in severe sepsis or septic shock stages of sepsis syndrome, its role in treatment of patients with sepsis who have not entered these stages remains to b...

Two stage total hip arthroplasty revision surgery includes foreign material debridment, insertion of antibiotic impregnatedcement spacer, and finally, reimplantation of the prosthesis. This review has aimed to evaluate the efficacy of antibioticimpregnated cement spacers in infection control and eradication in arthroplasties.A total of 85 articles on total hip arthroplasty wer...

Chronic osteomyelitis of the mandible is usually a difficult pathology to resolve. Treatment has included long-term antibiotics, and surgical debridement, aggressive in some cases. This paper reports a 54-year-old female with an eight-month-mandibular chronic osteomyelitis who was successfully treated with the combination of medication and surgical intervention.

Ventilator-associated pneumonia (VAP) has traditionally been treated with a 14–21day course of antibiotics. However, prolonged antibiotic therapy is associated with the emergence of multidrug-resistant strains, as well as higher toxicity and costs. In a large, randomised, controlled trial in patients with microbiologically confirmed VAP who received appropriate empirical antibiotic therapy, an ...

OBJECTIVE There is considerable variation in practice regarding the use of prophylactic antibiotic therapy in spinal operations. To date, individual studies have not demonstrated a significant benefit for prophylactic antibiotic therapy in spinal operations. METHODS Systematic database searches for randomized prospective trials of prophylactic antibiotic therapy in spinal surgery, general neu...