anti-neutrophil cytoplasmic autoantibodies have been detected in patients with some autoimmune and vascular diseases such as wegner's granulomatosis, polyarthritis nodosa and systemic lupus erythematosus. indirect immunofluorescence technique has been employed to detect these autoantibodies. by this method, two general patterns of antineutrophil cytoplasmic antibodies were seen: a cytoplasmic (...

aim : the aim of this study was to discuss the prevalence of celiac disease (cd) in dyspeptic patients. background : although severe mucosal abnormality with villous atrophy (lesions marsh iii) is at present the gold standard for the diagnosis of cd, presentation with non-specific microenteropathy (marsh i-ii) with positive serology is also common. patients with dyspepsia, specific cd antibodie...

Antibody drug conjugates (ADCs) are a new class of drugs that combine chemosynthetic with antibody through linker. the targeting characteristics traditional cytotoxic small molecule drugs, while reducing side effects both making them kind “biological missile” and representing relatively evolving anti-cancer drugs. Antibody-coupled currently used in many solid tumors, this article reviews clinic...

background: cigarette smoking has been linked with the suppression of immune responses and increased susceptibility to numerous infections in humans. tetanus is also a major public health problem in many countries. the aim of the present study was to evaluate the serum levels of anti-tetanus toxin antibodies in c igarette smoking and healthy non-smoking people .   materials and methods: a total...

introduction: antifertility effects of naturally occuring antisperm antibody (asa) in infertile couples and studies on experimental immunization of various animals with sperm antigens represent asa as an immunocontraceptive target. the effects of different factors on sperm immunogenecity and asa production have been studied and different results have been reported. in this study, whole sperm im...

background: the prevalence of anti-neutrophil cytoplasmic antibodies (ancas) and anti-cardiolipin antibodies (anti-cl ab) in behcet’s disease (bd) and also their roles in vascular involvement is controversial. objective: to assess the prevalence of ancas and anti-cl ab as well as their correlations with clinical manifestations in iranian patients with bd. methods: in this case/control study, th...

background:epidermal growth factor receptor (egfr) overexpression is a characteristic of several malignancies and could be considered as an excellent target for designing specific inhibitors such as anti-egfr monoclonal antibodies for cancer therapy. drawbacks exerted by large sizes of full-length antibodies have lead to the development of single chain antibodies, which benefit from having smal...

A murine IgM monoclonal antibody (MA-2C6) with κ-light chains directed against an antigenic determinant of outer surface protein A (OspA) of the Lyme disease spirochete, Borreliaburgdorferi, is produced. This antibody could bind specifically to OspA antigen of several isolates of B. burgdorferi, but not to the non-Lyme disease bacteria such as T. pallidum and B. hermsii. Antibody MA-2C6 was pur...