acylisothiocyanate (1) was allowed to react with benzylidene malononitrile producing oxazine derivative (2). also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinotetrazole derivative (4). the reaction of acetylacetone with compound (1) gave pyridine derivative (5) by intramolecular cycloaddition while it was reacted with n-methyl aniline ...

objective(s): gastric cancer is the first and second leading cause of cancer related death in iranian men and women, respectively. gastric cancer management is based on the surgery, radiotherapy and chemotherapy. in the present study, for the first time, the beneficial effect of saffron (crocus sativus l.) aqueous extract (sae) on the 1-methyl-3-nitro-1-nitrosoguanidine (mnng)-induced gastric c...

gonadotropin releasing hormone (gnrh) plays a key role in reproduction. this decapeptide is synthesized and released by hypothalamus and induces the pituitary gonadotrop cells to release pituitary gonadotropin hormones. in some extrapituitary compartments gnrh and its receptor act as part of the autocrine regulatory system of cell proliferation. the anticancer activity of gnrh and its analogues...

this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

many anticancer drugs in clinical use interact with dna through intercalation, which is process that starts with the transfer of the intercalating molecule from an aqueous environment to the hydrophobic space between two adjacent dna base pairs. in general, intercalatig agents are two types: monofunctional and bifunctional. monofunctional intercalators contain one intercalating unit and bifunct...

cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. the identification of new cytotoxic drugs with low side effects on immune system has developed as important area in new studies of immunopharmacology. thymoquinone (tq), derived from the medicinal spice nigella sativa (also called black cumin) ex...

background: present investigations were carried out to evaluate an ethanolic extract of oxalis corniculata linn. for its anticancer and antioxidant activity in ehrlich acsites carcinoma (eac) - induced in swiss albino mice. methods: cancer was induced in mice by aspiration of peritoneal fluid of eac inoculated mice and diluted to get 1x10 6 cells/ml in phosphate buffer. cancerous animals were d...

BACKGROUND/AIM DNA topoisomerases are ubiquitous enzymes that regulate conformational changes in DNA topology during essential cellular processes, and, for this reason, have been characterized as the cellular targets of a number of anticancer drugs. Bortezomib is a powerful proteasome inhibitor used in the treatment of hematological malignancies. In this study, we investigated the inhibitory ef...

BACKGROUND Pregnant patients with cancer are increasingly treated with anticancer drugs, although the specific impact of pregnancy-induced physiological changes on the pharmacokinetics (PK) of anticancer drugs and associated implications for optimal dose regimens remains unclear. Our objectives were to quantify changes in PK during pregnancy for four frequently used anticancer agents doxorubici...

In this paper, mesoporous silica nanoparticles (MSNs) were studied as vehicles for the delivery of the antitumoral drug gemcitabine (GEM) and of its 4-(N)-acyl derivatives, (4-(N)-valeroyl-(C5GEM), 4-(N)-lauroyl-(C12GEM) and 4-(N)-stearoyl-gemcitabine (C18GEM)). The loading of the GEM lipophilic prodrugs on MSNs was explored with the aim to obtain both a physical and a chemical protection of GE...