نتایج جستجو برای: anticancer activity
تعداد نتایج: 1156826 فیلتر نتایج به سال:
Two series of podophyllotoxin derivatives were synthesized by addition a 4?-sulfanilamide to or substitution 4?-amide into podophyllotoxin. Their cytotoxicities evaluated against four human cancer cell lines (A549, HeLa, MCF-7, and PC-3). Investigations the structure–activity relationship generalized. Derivative 9f (2-thienoylaminoepipodophyllotoxin) exhibited highest activity cells, inhibiting...
Cancer is the second leading cause of death in the world. Despite advances in the diagnosis and treatment, overall survival of patients still remains poor. Hence, there is an urgent need for development of new anticancer agents. Considering promising biological activity of 1,3,4-thiadiazole derivatives, in the present study, synthesis and cytotoxicity assessment of new derivatives of this ring ...
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