Over expression of Protein kinase (CK2) suppresses apoptosis induced by a variety of agents, whereas down-regulation of CK2 sensitizes cells to induction of apoptosis. In this study, we have built quantitative structure activity relationship (QSAR) models, which were trained and tested on experimentally verified 38 enzyme׳s inhibitors having inhibitory value IC50 in µM. These inhibitors were do...

there are considerable efforts to identify naturally occurring substances as new drugs in cancer therapy. many components of medicinal plants have been identified that possess substantial anticancerous properties. this prompted us to investigate the effect of scrophularia striata (an iranian species belonging to the scrophulariace family) extract on the growth of astrocyte cancer cell line (132...

Nanotechnology being undoubtedly an uncut gem over the past few years has been in sighting as a new form of branch with its vigorous discoveries which have led to divergent evolution giving emergence not only pathway knowledge but also developing technological techniques. The constituting nanoparticles and versatile properties dynamic structures made major breakthrough for role biotechnology ar...

Arginases play important roles in the metabolic pathways determining fitness of both immune and tumour cells. ARG1 expressed by myeloid cells microenvironment (TME) contributes to suppression effector functions T NK a local L-arginine depletion, while ARG2 constitutes cell-autonomous regulator cytotoxic regulatory lymphocytes. is highly various cancers its significant role cancer has recently e...

background: herbal medicine is a new complementary strategy for treating diseases such as cancer. however, its mechanism of action is not clear yet. this study investigates antitumor efficacy of polygonum avicular extract on mcf-7 cell line . methods: mcf-7 cells were treated with different concentrations of (50, 100, 150, 200, 250, 300,350 400 ng/âµl) polygonum avicular at different time inter...

Colorectal cancer is closely associated with environment, diet and lifestyle. Normally it is treated with surgery, radiotherapy or chemotherapy but increasing systemic toxicity, resistance and recurrence is prompting scientists to devise new potent and safer alternate prophylactic or therapeutic strategies. Among these, probiotics, prebiotics, synbiotics, and metabiotics are being considered as...