BACKGROUND Patients with cancer have a substantial risk of recurrent thrombosis despite the use of oral anticoagulant therapy. We compared the efficacy of a low-molecular-weight heparin with that of an oral anticoagulant agent in preventing recurrent thrombosis in patients with cancer. METHODS Patients with cancer who had acute, symptomatic proximal deep-vein thrombosis, pulmonary embolism, o...

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several decades and is still widely used in clinical practice for a variety of indications. The anticoagulant activity of heparin is mainly attributable to the action of a specific pentasaccharide sequence that acts in concert with antithrombin, a plasma coagulation factor inhibitor. This observation has led to the d...

Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis Platelet-mediated primary haemostasis and blood coagulation have evolved as important defence mechanisms against bleeding. The formation of the platelet plug provides the initial occlusion of the vascular lesion. This is temporally co-ordinated with the activation of the coagulation system, which occurs in resp...

Cutaneous reactions have been reported during anticoagulant therapy with coumarin derivatives, unfractionated and low molecular weight heparins, heparinoids, danaparoid and hirudins. Anticoagulant-induced skin reactions vary from local allergic manifestations to skin necrosis. In patients with allergic reactions, diagnosis and crossreactions between anticoagulants can be confirmed by intracutan...

Fourteen patients were treated with anticoagulants during 15 pregnancies. Eleven had venous thrombosis, three with pulmonary embolism; three had prosthetic heart valves; and one had mitral stenosis with pulmonary hypertension. AU 15 were treated with heparin and 10 with warfarin. The mean duration of heparin therapy was 4-5 weeks and of warfarin 14 weeks. There were two minor episodes of recurr...

Anticoagulant drugs are involved in the prevention and management of cardiac valve disease, cardiac arrhythmia, prosthetic heart valve, pulmonary embolus, and cerebrovascular accident.[1] Patients who receive oral anticoagulant therapy (OAT), dental extractions is a common procedure. In the past, it was controversial that dental extractions in patients under anticoagulant therapy pose the probl...

The number of patients referred to hospital clinics for monitoring of oral anticoagulation continues to rise rapidly. Introduction of computer programs for the control of oral anticoagulation improves the quality of anticoagulant control in hospital clinics. This approach has now been extended to include patients managed in general practice. Results confirm that the quality of anticoagulation c...

Spinal vascular events related to Behçet's disease are relatively uncommon. Deep vein thrombosis is the most frequent vascular involvement. Anticoagulant therapy is a debated issue in Behçet's disease. In this case report, we present a patient with a delayed diagnosis of Behçet's disease after development of cervical epidural hematoma following anticoagulant therapy due to deep venous thrombosi...

PURPOSE This study evaluated the effectiveness of a protocol using platelet-rich plasma (PRP) to prevent bleeding after dental extraction in patients treated with anticoagulant oral therapy. MATERIALS AND METHODS Forty patients with mechanical heart-value replacement who were treated with anticoagulant oral therapy were selected for the study. Each patient was treated with PRP gel placed into...