neutralization effects of acorus calamus and withania somnifera root extracts were tested against echis carinatus venom. both plant extracts were effectively neutralized the various pharmacological activities induced by echis carinatus venom. about 0.14 mg of acorus calamus and 0.16 mg of withania somnifera root extracts were able to completely neutralize the lethal activity of 2ld 50 of echis ...

Background/Aim. Direct oral anticoagulants (DOACs) administration significantly interferes with coagulation as-says. The aim of the study was to evaluate effect DOACs and DOAC-Remove? on assays during thrombophilia testing. Methods. carried out from January 2019 end June 2020. It included 30 DOAC-treated patients, 14 females 16 males aged 23 63 (median age 47.6 years), tested for due venous thr...

temporary paralysis is a rare manifestation of envenoming following the yellow iranian scorpion, odontobuthus doriae (o. doriae). thus, to elucidate the underlying mechanism, we investigated the neurotoxic effect of venom in the sciatic nerve, the possible mechanism in a mice model. the neurotoxicity and temperature effects in the venom-induced neurotoxicity were examined using the mouse sciati...

the chitosan nanoparticles used widely as a drug delivery systems recently. in the present study the echis carinataus snake venom loaded chitosan nanoparticles were prepared based on ionic gelation of tripolyphosphate and chitosan. the nanoparticles physicochemical characteristics, stability and biological activity of encapsulated venom were studied. the particles were spherical in shape and th...

although some venoms and their isolated compounds have been shown to have antibacterial properties, most have not been investigated for such activity. echis carinatus is one of the most venomous snakes in the world and has an effective haematotoxic venom that destroys endothelial cells and causes haemorrhagia. in this study, the antibacterial activity of iranian snake echis carinatus venom agai...

background : envenomation by hemiscorpius lepturus is not painful and the clinical manifestations include bloody urine due to hemoglobinuria or hematuria, dermonecrotic reactions,cardiac arrhythmia and in minority of cases acute renal failure which may lead to death following disseminated intravascular coagulation in infants. cardiac effects of envenomation by h. lepturus venom including inotro...

A paradoxical task of the venom gland of snakes is the synthesis and storage of an instantly available suite of toxins to immobilize prey and the protection of the snake against its own venom components. Furthermore, autolysis of the venom constituents due to the action of venom metalloproteases is an additional problem, particularly among viperid venoms, which are typically rich in lytic enzym...

objective(s):cone snails are estimated to consist of up to 700 species. the venom of these snails has yielded a rich source of novel peptides. this study was aimed to study the analgesic effect of persian gulf conus textile and its comparison with morphine in mouse model. materials and methods: samples were collected in larak island. the venom ducts were isolated and kept on ice then homogenize...