In vitro experiments were conducted to determine whether the direct thrombin inhibitors argatroban and lepirudin can interfere with the results of lupus anticoagulant (LA) testing. Concentration-response curves were generated to calculate the concentration of anticoagulant that prolongs the activated partial thromboplastin time (aPTT) to 75 seconds (2.5 times the baseline average). Correspondin...

OBJECTIVE The Sydney classification criteria for antiphospholipid syndrome include lupus anticoagulant or moderate-to-high titre anticardiolipin IgG or IgM. We explored the association of all anticardiolipin isotypes, lupus anticoagulant and the combination with venous and arterial thrombosis. METHODS Patients with systemic lupus erythematosus (SLE) in a large clinical cohort seen quarterly w...

atrial fibrillation (af) is associated with inflammatory and hypercoagulability state. previous studies evaluated the safety and efficacy of dabigatran and warfarin in prevention of thrombothic complications. this study was intended to assess the influence of these drugs on hemostatic and inflammatory markers among patient underwent pulmonary vein ablation.   a total of 100 patients with af who...

We present functional and binding data relevant to the reported roles for prothrombin and beta 2-glycoprotein I (beta 2GPI) in the expression of lupus anticoagulant activity. In a purified system containing human prothrombin, Xa, Va, and a rate-limiting concentration of phosphatidylserine (PS)/phosphatidylcholine (PC) vesicles, the preliminary incubation of vesicles with protein A separated IgG...

background: the use of thrombolytic agents in the treatment of hemodynamically stable patients with acute submassive pulmonary embolism (pte) remains controversial. we, therefore, conducted this study to compare the effect of thrombolytic plus anticoagulation versus anticoagulation alone on early death and adverse outcome following submassive pte. methods: w e conducted a study of patients with...

Thrombosis, an imbalanced interaction between blood components, contributes greatly to deaths that occur worldwide. Therefore, treatment can reverse the condition of clotting and hypercoagulability is essential. However, drugs used treat thrombosis-based diseases have side effects be seen in short long term, particularly increased risk bleeding. alternative needed overcome problem thrombosis wi...