Capparis decidua is one of the traditional remedies used for various medicinal treatments in Pakistan. This study presents the determination of proximate composition, amino acids, fatty acids, tocopherols, sterols, glucosinolate and phenolic content in extracts obtained from different aerial parts of C. decidua, as well as their antidiabetic and antioxidant activity. All examined extracts were ...

The aim of the present study was to investigate the antidiabetic and renal protective effect of Momordica dioica extract (MDMtE) in streptozotocin-diabetic rats. MDMtE treatment markedly reduced serum glucose, increased serum insulin and urea levels. Study results indicated that the antioxidant enzyme activity of kidney was increased, while thiobarbituric acid reactive substances (TBARS) were r...

The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570 +/- 29 to 401 +/- 59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significan...

In the present work the antidiabetic activity of the Mallotus philippinensis was evaluated. The hydroethanolic bark extract showed significant increase in the levels of body weight, insulin and significant decrease in blood glucose, and glycosylated haemoglobin when administered orally for 30 days to STZ induced diabetic rats at a dose of 200 and 400mg/kg body weight. Phytochemical studies also...

The management of diabetes in the month of Ramadan can be very challenging. On one hand there is the issue of fasting associated hypoglycaemia, and on the other, fasting as well as post prandial hyperglycaemia. Under such circumstances, a planned regimen needs to be followed to keep the blood glucose levels under control. The same oral antidiabetic agents that were used prior to the fast are us...

Diabetes mellitus is a major health problem due to its increasing prevalence and life-threatening complications. Antidiabetic sulfonylureas represent the first-line drugs in type 2 diabetes even though the most common associated risk is pharmacologically-induced hypoglycemia. In the development of this side effect are involved several factors including the pharmacokinetic and pharmacodynamic pr...

The nuclear receptors constitute one of the largest groups of transcription factors known today. The peroxisome proliferator-activated receptors (PPAR) are members of the nuclear receptor supergene family and are considered as key sensors of both lipid and glucose homeostasis. The role of the PPAR γ isoform in glucose metabolism is illustrated by the fact that antidiabetic thiazolidinediones ha...

It is the fact that diabetes can't be cured and it has never been reported that someone had recovered totally from diabetes. The rapidly increasing incidence of diabetes mellitus is becoming a serious threat to mankind health in all parts of the world. Moreover, during the past few years some of the new bioactive drugs isolated from plants showed antidiabetic activity with more efficacy than or...