Public academic research sites, private institutions as well as small companies have made substantial contributions to the ongoing development of antidiabetic vanadium compounds. But why is this endeavor not echoed by the globally operating pharmaceutical companies, also known as "Big Pharma"? Intriguingly, today's clinical practice is in great need to improve or replace insulin treatment again...

OBJECTIVE To evaluate the prevalence of racial and ethnic disparities of antidiabetic treatment among residents of long-term care facilities in five states. RESEARCH DESIGN AND METHODS Retrospective, cross-sectional study of 50,427 elderly nursing home residents with diabetes in New York, South Dakota, Kansas, Mississippi, and Ohio between 1993 and 1997. RESULTS Thirty to fifty percent of r...

Banaba (Lagerstroemia speciosa Pers) leaves has been used as tea or decoction type in the Philippines for blood sugar control and used in the treatment of diabetes in India and contain a treterpenoid compound know as a corosolic acid which can promote the absorption and utilization of glucose in the cell by transporting the stimulated glucose. As such, banaba plays a role in regulating levels o...

OBJECTIVE To review the recent literature (January 2000-November 2005) regarding the impact of antidiabetic medications and glycemic control on the overall costs of care for patients with diabetes in U.S. managed care organizations (MCOs). SUMMARY The pharmacy component accounts for typically 20% to 30% (full range, 10%-65%) of overall costs for MCO patients with diabetes. About 30% of pharma...

The role of metformin in prostate cancer chemoprevention remains unclear. REDUCE, which followed biopsy-negative men with protocol-dictated PSA-independent biopsies at 2- and 4-years, provides an opportunity to evaluate the link between metformin use and prostate cancer diagnosis with minimal confounding from screening biases. In diabetic men from REDUCE, we tested the association between metfo...

BACKGROUND Impaired glucose tolerance, impaired fasting glucose, and elevated hemoglobin A(1c) are intermediate stages, considered prediabetes, a precursor to overt type 2 diabetes mellitus. Prediabetes is associated with increased risk for cardiovascular disease, independent of diabetes development. Data have shown that various oral antidiabetic drugs can help people regress from prediabetes t...

peganum harmala is a plant that is traditionally used as an analgesic, anti-inflammatory, antibacterial, antioxidant, anti-helmintic, and antimutagenic agent. moreover, it is used to treat a variety of human ailments, including depression. this study was conducted to investigate the antidiabetic activity of hydro alcoholic extract of this herb. a hydro alcoholic extract from seeds of this herb ...

Introduction Although a number of researchers have considered the positive potential of Clinical Decision Support System (CDSS), they did not consider that patients' attitude which leads to active treatment strategies or HbA1c targets. Materials and Methods We adopted the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) published to propose an ...

OBJECTIVES Bidens species are used for their antidiabetic properties traditionally in many countries. Aim of this study is to evaluate hypoglycaemic and antidiabetic activity of Bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. MATERIALS AND METHODS Hypoglycaemic effects of B. tripartita extract and its sub-extracts were investigate...

The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly understood. Hence, the main aim of this work was to investigate the antioxidant and antidiabetic propert...