Flavonoids are polyphenol compounds that exert many potential health benefits, including diabetes type-II, which is the third most common disease causes death, right after cancer and cardiovascular diseases. The excessively high level of blood glucose has been believed to trigger type II diabetes. aim this review describe flavonoid's ability as an alternative treatment for type-II patients. Thi...

OBJECTIVE To analyze drug prescriptions for insulin and oral antidiabetic drugs in type 1 and type 2 diabetes mellitus patients seen in the Brazilian Public Healthcare System (Unified Health System - SUS) in Ribeirao Preto, SP, Brazil. SUBJECTS AND METHODS All the patients with diabetes seen in the SUS in the western district of Ribeirao Preto, SP, Brazil between March/2006 and February/2007 ...

The most well-known mechanism of metformin action, one of the most commonly prescribed antidiabetic drugs, is adenosine monophosphate-activated protein kinase activation; however, recent investigations have shown that adenosine monophosphate-activated protein kinase-independent pathways can explain some of metformin's beneficial metabolic effects as well as undesirable side-effects. Such novel ...

Plants have always been a source of drugs for humans since time immemorial. The Indian traditional system of medicine is replete with the use of plants for the management of diabetic conditions. According to the World Health Organization, up to 90% of population in developing countries use plants and its products as traditional medicine for primary health care. There are about 800 plants which ...

The genus, Salacia belongs to the family, Celastraceae and is distributed across the world. Roots and stems of Salacia are used mainly as antidiabetic agents in traditional system of medicine such as Ayurveda and Unani. The roots are either chewed directly or taken in dried powdered form or as decoction. Apart from antidiabetic activity, several species of the genus Salacia are known to possess...

The current oral blood glucose lowering agents and dietary measures only partially correct the multiple metabolic defects in NIDDM with insulin resistance remaining relatively impervious to treatment Hypoglycaemia and secondary failure are common with presently available sulphonylureas and hence the need for newer blood glucose lowering drugs. In case of NIDDM, a successful new drug should corr...

In October 1955 three reports in the Deutsche Medizinische Wochenschrift' described a new sulfonamide derivative possessing the ability when given by mouth to reduce normal blood sugar values to subnormal, and elevated blood and urine sugar values in diabetes to normal. Reduction of normoglycemia had been shown with other sulfonamide derivatives as early as 1942," but the application to therapy...

Aims : The present study evaluates the antidiabetic activity of Swertia chirata (aqueous extract) on the blood glucose level of streptozotocin induced diabetic rat models. Objectives : i) To study the antidiabetic activity of aqueous extract of Swertia chirata in streptozotocin induced diabetes in albino rats. ii) To compare the antidiabetic activity of Swertia chirata extracts with that of sta...

The present study evaluated antidiabetic activity of hydroalcoholic extract of Sansevieria roxburghiana rhizome (HASR) in streptozotocin-induced diabetic rats. Hyperglycemia was induced in rats by streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, diabetic rats received HASR orally at 50 and 100 mg/kg body weight daily for 15 days. Glibenclamide (0.5 mg/kg, orally) serv...