PURPOSE To evaluate the effectiveness of a pharmacist-led educational interview in terms of adherence to antiepileptic drug administration among adult patients with epilepsy. METHOD Sixty adult patients with epilepsy who fulfilled the inclusion criteria were recruited. A pharmacist-led educational interview was conducted with the intervention group (n=30). Patients in the control group (n=30)...

The current study is a systematic review of the literature concerning the possible relationship of antiepileptics and suicide-related clinical features and behaviours. A MEDLINE search returned 863 papers but only five were chosen as relevant. A critical analysis of the Food and Drug Administration report is also included. Overall, the current review suggests there are no convincing data concer...

Normal and Abnornml De the Human Nervous Syste Lemire, J. D. Loeser, R. VN -.E. C. Alvord. (Pp. 421 $27.50.) Harper and Row USA. 1975. 'Fills a long-felt gap' is a viewers but the phrase is ii this book. In a clear an way it gathers together a of information about the and growth of the hun system and gives a brief the major developmental Standardised graphs pres formation in a manner rapid refe...

In a recent CMAJ commentary on drug interactions with warfarin, David Juurlink overlooked a very important category of drugs that interact with warfarin: antiepileptic drugs. Phenytoin, carbamazepine and phenobarbital are potent inducers of the cytochrome P450 system, and their interactions with warfarin have been known for decades. These drugs can substantially increase the rate at which warfa...

Antiepileptic drugs (AEDs) are designed to prevent and suppress seizure activity. Their effects on calcium influx and molecular cascades contributing to necrotic and apoptotic neuronal death, however, suggests that they have functions other than just suppression of excitability. The neuroprotective effects of 20 AEDs currently in use or being investigated in Phase II - III clinical trials for t...