Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents ...

Candida albicans is the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combinatio...

The development of resistance to current antifungal therapeutics drives the search for new effective agents. The fact that several acetophenone-derived Mannich bases had shown remarkable antifungal activities in our previous studies led us to design and synthesize some acetophenone-derived Mannich bases, 1-8 and 2-acetylthiophene-derived Mannich base 9, 1-aryl-2-dimethylaminomethyl-2-propen-1-o...

BACKGROUND Patients with hematological malignancies often develop febrile neutropenia (FN) as a complication of cancer chemotherapy. Primary or secondary antifungal prophylaxis is recommended for patients with hematological malignancies to reduce the risk of invasive fungal infection (IFI). This study retrospectively evaluated the efficacy and potential harm of administration of primary and sec...

Systemic and invasive mycoses caused by primary and opportunistic fungal pathogens have been emerging as global problems because of the increase in the number of immunocompromised individuals, due to solid-organ transplants, anti-cancer chemotherapy, and extended human lifespan. A recent report estimated that fungal pathogens, such as Cryptococcus neoformans, Candida albicans, and Aspergillus f...

OBJECTIVES To assess the total outpatient systemic antimycotic and antifungal use in Europe, and to identify the antimycotic and antifungal substances most commonly used. METHODS Within ESAC (www.esac.ua.ac.be), using the anatomical therapeutic chemical (ATC) and defined daily dose (DDD) classification, data on outpatient use of all 14 antimycotics (12) and antifungals (2) for systemic use (A...

in this study, we investigated the antifungal effects of silver nanoparticles (ag-nps) on candida albicans (atcc 5027), saccharomyces cerevisiae (atcc 5027). investigating method by using minimum inhibitory concentration (mic) technique, some of drugs including amphotericin b, fluconazole and synthesized ag-nps have been obtained on the fungi and the changes on membrane reactions of yeasts have...

in this study, antifungal property of olive leaf extracts against candida albicans ptcc-5027 was examined. fresh olive leaf extracts were prepared using distilled water in a soxhlet apparatus. the antifungal activity of the extract was analyzed by measuring the minimum inhibitory concentration (mic) and minimum fungicidal concentration (mfc), using the microdilution test and disc diffusion assa...

Skin infection caused by Tricophyton rubrum and some opportunistic fungi such as Candida. Albicance and Aspergillus. fumigatus occur in various parts of the body and sometimes are difficult to be treated. Antifungal effects of spherical silver nanoparticles (nano-Ag) were investigated in this study. Although silver nanoparticle has long been used as effective inorganic antifungal agent; the ant...

Highly stabilized monodispersed silver nanoparticles (AgNPs) were synthesized by Rhizopus stolonifer and the antifungal efficacy of silver nanoparticles (AgNPs) against Candida sp. were studied. Characterization of biosynthesized nanosilver was made by TEM-EDS and AFM. Minimum Inhibitory Concentration (MIC) of biosynthesized AgNPs, Amphotericin B, and Fluconazole have been studied on pathogenic...