The aim of the present study was to formulate and evaluate nystatin containing thermosensitive mucoadhesive gel for vaginal drug delivery to achieve prolonging the residence time, sustained drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance in the treatment for vaginal candidiasis. Here nystatin (1%) as a model drug. A 3 full factorial design was employed...

The present study was designed to evaluate the antifungal activity of Azima tetracantha extracts and isolated compound (friedelin) against fungi. Antifungal activity was carried out using broth microdilution method and fractions were collected using (silica gel) column chromatography. The antifungal activity of Azima tetracantha crude extracts and isolated compound (friedelin) were evaluated us...

Similarities in fungal and animal cells make antifungal discovery efforts more difficult than those for other classes of antimicrobial drugs. Currently, there are only three major classes of antifungal drugs used for the treatment of systemic fungal diseases: polyenes, azoles, and echinocandins. Even in situations where the offending fungal organism is susceptible to the available drugs, treatm...

conclusions antimicrobial and antitoxigenic properties of natural products need a firmly established criterion before they could be offered to application. results a significant reduction in aflatoxin production was noted which was not due to the inhibitory effect but because of antifungal property of the oil. interestingly, the oil promoted toxin production for the reasons yet to be investigat...

The antifungal activity of aqueous, petroleum ether, benzene, chloroform, methanol and ethanol extracts and alkaloid extract of Prosopis juliflora (Sw.) DC. leaves (Mimosaceae) was evaluated for antifungal activity by poisoned food technique against Alternaria alternata a causal organism of brown spot of tobacco. Aqueous extract recorded highly significant antifungal activity at 24% concentrati...

Previously, VpPR-10.1 was isolated and characterized from a cDNA library of a fungus-resistant accession of Chinese wild grape (Vitis pseudoreticulata). We found that expression of VpPR-10.1 is affected by the fungal pathogen Erysiphe necator. To investigate the biochemical basis of the nuclease activity of VpPR-10.1 and its role in antifungal resistance, we generated recombinant VpPR-10.1 as w...

We found that amiodarone has potent antifungal activity against a broad range of fungi, potentially defining a new class of antimycotics. Investigations into its molecular mechanisms showed amiodarone mobilized intracellular Ca2+, which is thought to be an important antifungal characteristic of its fungicidal activity. Amiodarone is a synthetic drug based on the benzofuran ring system, which is...

Aneurinibacillus: sp. YR247 was newly isolated from the deep-sea sediment inside the Calyptogena community at a depth of 1171 m in Sagami Bay. The strain exhibited antifungal activity against the filamentous fungus Aspergillus brasiliensis NBRC9455. A crude extract prepared from the YR247 cells by ethanol extraction exhibited broad antimicrobial activities. The antifungal compound is stable at ...