This work analyses the chitin-binding and catalytic domains of the human macrophage chitotriosidase and investigates the physiological role of this glycoside hydrolase in a complex mechanism such as the innate immune system, especially its antifungal activity. Accordingly, we first analyzed the ability of its chitin-binding domain to interact with chitin embedded in fungal cell walls using the ...

Background: Fungal corneal ulcer is the most dangerous and challenging type of infective keratitis.  Since most of the ophthalmic antifungal drops are scarce and expensive in developing countries, attempts have been made to study fungicidal property of some readily available antiseptic agents as a substitute.  Povidone iodine (PI) and chlorhexidine gluconate (CHx) has been postulated to be effe...

Natural dye extracted from aerial parts of Barleria prionitis and different kinds of textile fabrics dyed with the natural dye were investigated for their antifungal activity. Antifungal activity of natural dye and dyed fabrics was assessed against standard strains of five fungi namely Aspergillus flavus, A. niger, A. parasiticus, Fusarium moniliforme and Penicillium canescens using agar-we...

Bacilli with fibrinolytic activities were isolated from traditionally-prepared Meju and some of these strains showed strong antifungal activities. One isolate, MJ1-4, showed the strongest antifungal activity. MJ1-4 and other isolates were identified as B. amyloliquefaciens strains by recA gene sequencing and RAPD-PCR results. B. amyloliqufaciens MJ1-4 efficiently inhibited an Aspergillus spp.-p...

Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of currently available antifungals, molecular mechanisms of antifungal resistance will be detailed. It...

OBJECTIVE The aim of this study is to analyze the expenditures related to the use of antifungal drugs in patients with hematological malignancies. METHODS In this retrospective study, the expenditures related to use of antifungal drugs for treatment of invasive fungal infections in patients with hematological malignancies between November 2010 and November 2012 were analyzed. Expenditures of ...

PURPOSE This in vitro study sought to compare the antifungal activity of melaleuca alternifolia oil and fluconazole mixed with a tissue conditioner. MATERIALS AND METHODS By testing several concentrations of fluconazole and melaleuca oil in Visco-gel, the minimum most effective concentration of each antifungal agent against Candida albicans was determined. Mean inhibition diameter (MID) was u...

OBJECTIVE To address the putative association of antibiotic use and subsequent yeast vaginitis in a population of non-pregnant women. METHODS Three hundred and sixteen women who received medical care in rural family medicine clinics enrolled in this study. Participants were pre-menopausal and non-pregnant and were followed until they used a course of antifungal therapy for vaginitis, became p...