Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains examined. The compounds showed moderate in vitro antimalarial two P. falciparum strains, 3D7 (CQ susceptible clone) Dd2 resistant clone). Three aminoquinolines were further examined for efficacy a mouse model using modified Thompson test. In this model, mice infected with berghei-infec...

The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of resistance acquisition. Unfortunately, antimalarial combination therapy is limited by the depleting repertoire of effective drugs with distinct target p...

Sir: In the course of our program to discover antimalarial antibiotics active against drug-resistant parasites, by screening soil microorganisms and antibiotic library of the Kitasato Institute for Life Sciences, we previously reported on various microbial metabolites exhibiting potent antimalarial properties . Now, we find that prumycin , a compound in the antibiotic library of our institute, ...