Scrophularia umbrosa is a medicinal plant used as a traditional herb. This study was designed to investigate the phytochemical analysis of methanol (MeOH), DCM, and n-Hexane extracts of rhizome as well as total phenol and total flavonoid contents (TPC and TFC). In-vitro β-hematin formation assay and DPPH method were applied for analyzing antimalarial and free-radical scavenging activities of th...

Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial activity, in spite of the fact that kalihinol A is the most potent among the members of the larger family of antimalarial isocyanoterpenes. We have validated a strategy designed to access many of the kalihinanes with a 12-step enantioselective synthesis of kalihinol B, the tetrahydrofuran isomer of k...

In this article, a review on bioactive flavonoids that are abundant in medicinal and functional food (dietary) plants has been made, with special reference to antimalarial flavonoid molecules. Flavonoids have been found to exist in plants/plant medicines with a wide structural diversity consisting of numerous polyphenolic compounds and having well defined molecular target specificity. These phy...

BACKGROUND The majority of the Ethiopian population is at risk of malaria largely caused by Plasmodium falciparum. The resistance of the parasite to existing drugs is the main challenge in the control of the disease and thus new therapeutic drugs are required. In Ethiopia, people use different plant species to treat malaria. However, very few of them have so far been evaluated for their safety ...

OBJECTIVE To determine if low-dose weekly chloroquine (CQ) therapy improves recovery from malaria-associated anaemia. DESIGN Proof of concept randomised clinical trial. SETTING West Kiang District, Lower River Region, The Gambia. PARTICIPANTS Children resident in participating communities, aged 12-72 months, with uncomplicated malaria identified using active case detection over two consec...

Coleus hadiensis (Forssk.) A.J.Paton is a horticultural herb that goes to the Lamiaceae family. This plant species has been using treat diarrhea, skin and digestive disorders, diabetes, carcinoma in ethnomedicines. minireview work purposes analyze, summarize, document reported bioactivities of C. hadiensis. Suitable published works were obtained employing Web Science, Scopus, PubMed, Semantic S...

Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes preclinical murine and experimental human infection studies to evaluate efficacy.