The specific activities of antioxidant enzymes, [eg superoxide dismutases (SOD), glutathione peroxidase (GPX) and catalase (CAT)], anthropometric measurements, including waist/hip ratio of 48 male and 167 female overweight persons (body mass index (BMI) ≥25.0 kg/m) compared with a 26 male and 80 female control group (BMI = 18.5-24.9 kg/m) of Thai volunteers who attended the Out-patient Departme...

Reactive oxygen species (ROS) are generated as a result of normal cellular metabolism, mainly through the mitochondria and peroxisomes, but their release is enhanced by the activation of oxidant enzymes such as NADPH oxidases or downregulation of endogenous antioxidant enzymes such as manganese-superoxide dismutase (MnSOD) and catalase. Transforming growth factor-β (TGF-β), found to be overexpr...

Oxidative stress is one of the mechanisms with a central role involved in the pathogenesis of myocardial infarction. The protective effect of glutamine on myocardial antioxidant defense system was investigated during isoprenaline-induced myocardial infarction, an animal model of myocardial infarction of human beings. Levels of diagnostic marker enzymes in plasma, reduced glutathione (GSH) and l...

BACKGROUND High oxidative stress and chronic inflammation can contribute to the pathogenesis of coronary artery disease (CAD). Coenzyme Q10 is an endogenous lipid-soluble antioxidant. Statins therapy can reduce the biosynthesis of coenzyme Q10. The purpose of this study was to investigate the effects of a coenzyme Q10 supplement (300 mg/d; 150 mg/b.i.d) on antioxidation and anti-inflammation in...

This study was undertaken in order to investigate the effect of deoxynivalenol on the oxidative status and antioxidant defense of HepG2 cells. The HepG2 cells were exposed to 2.5 μM deoxynivalenol for 6, 12 and 24 hours. Higher (p<0.01) activities of the antioxidant enzymes such as superoxide dismutase and catalase were observed after 12 and 24 hours of mycotoxin exposure, while, for the same t...

The effects of the exudate of Aloe barbadensis leaves on oxidative stress and some antioxidant status of streptozotocin induced diabetic rats were studied. There was significant reduction in scavenging enzymes like superoxide dismutase (SOD) activity and significant increase in signs of oxidative tissue damage, such as lipid peroxidation products (plasma MDA) in streptozotocin induced diabetic ...

BACKGROUND & OBJECTIVES Oxidative stress is incriminated to play a central role in the pathogenesis of Parkinson's disease (PD). Oxidative stress, to which neurons are highly susceptible, is also known to induce oxidative changes in human red blood cells (RBCs), in vivo and in vitro. Earlier studies on oxidative stress in RBCs in patients with PD have yielded controversial results claiming unal...

We have measured lipid peroxidation and the activity of antioxidant enzymes in lenses of alloxan injected rats. After 12 weeks alloxan treated rats developed lens cataract. Diabetes rats had both lower lens weight and lower level of proteins in soluble fraction of lens homogenate. Alloxan treatment is associated with a significant increase of thiobarbituric acid reactive substances and the acti...

As a safeguard against oxidative stress, the balance between the main antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) was believed to be more important than any single one, for example, dual-functional SOD/CAT enzyme has been proved to have better antioxidant ability than either single enzyme. By combining traditional fusion protein tec...

The present investigation was executed with an objective to study the effects of Co stress in Arachis hypogaea L. with special emphasis on antioxidant enzymes activities which are the defense mechanism to any type of abiotic stress. In this we have analysed the effect of cobalt (Co) stress on antioxidant enzyme activities (catalase, peroxidase and polyphenol oxidase) of Arachis hypogaea L. were...