The antioxidant property of jionoside D, isolated from Clerodendron trichotomum (Verbenaceae), was investigated. This compound showed scavenging activity of intracellular reactive oxygen species and of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as lipid peroxidation inhibitory activity. This radical scavenging activity of jionoside D protected the cell viability of Chinese hamster lu...

Introduction: The phytochemicals in medicinal plants are defined as bioactive non nutrient plant compounds in fruits, vegetables and grains that have been linked to reducing the risk of major chronic diseases. The medicinal plant are promising to have such have effective medicinal property due to presence of phytochemical compounds like alkaloids, tannins, flavonoids and phenolic compounds. The...

Reactive oxygen species (ROS) are natural byproducts of oxidative respiration that are toxic to organs and tissues. To mitigate ROS damage, organisms have evolved a variety of antioxidant systems to counteract these harmful molecules, however in certain pathological conditions these protective mechanisms can be overwhelmed. We have recently demonstrated that Peptide Inhibitor of Complement C1 (...

In the second experiment as reported in the previous chapter, an anti cataract activity of Captopril against oxidant stress induced cataract was investigated attributed to its antioxidant properties. The antioxidant property of Captopril is greatly influenced by the presence of thiol group in its structure which helps to interact with lens specific enzymes and proteins as well. After absorption...

Background Oxidative stress has been implicated in the pathogenesis of hypertension and antioxidant compounds have been used in the prevention and treatment of this disease. In this context, coconut oil (CO) was found to have antioxidant property due to its high polyphenol content. In this study, we investigated the effects caused by chronic treatment with CO on mean arterial pressure (MAP), he...

Recently, it started gaining more medicinal value because of the antioxidant property because of ascorbic acid and lycopene content (Anon., 2000). Hence tomatoes are called as poor man’s apple (Rick, 1969). Tomatoes offer significant nutritional advantages, including providing a significant source of dietary lycopene, β-carotene, carotenoids, vitamin C, potassium, fiber, color, flavor and antio...

The scientists at ALMPG Institute of Basic Medical Sciences, University of Madras, Chennai, India evaluated a combination of spices (Piper nigrum Linn., P. longum Linn. and Zingiber officinale Rosc.), herbs (Cyperus rotundus Linn. and Plumbago zeylanica Linn.) and salts make up Amrita Bindu for its possible antioxidant activity. The study was focused to evaluate the antioxidant property of indi...

Oxidative stress defines a condition in which the prooxidant-antioxidant balance in the cell is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells' viability. Probiotics have been known for many beneficial health effects, and the consumption of probiotics alone or in food shows that strain-specific probiotics can pre...

Heart failure is defined as a disruption of circulatory homeostasis. We have demonstrated that baroreflex dysfunction strikingly disrupts circulatory homeostasis. Moreover, previous many reports have suggested that central excess oxidative stress causes sympathoexcitation in heart failure. However, the central mechanisms of baroreflex dysfunction with oxidative stress has not been fully clarifi...