New antibiotic pumilacidins A, B, C, D, E, F and G were isolated from the culture broth of a strain of Bacillus pumilus. They are cyclic acylheptapeptide composed of a beta-hydroxy fatty acid, two L-leucine, two D-leucine, L-glutamic acid, L-aspartic acid and L-isoleucine (or L-valine). Pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K(+)-ATPase and demonstrated an...

OBJECTIVE H(2) blockers have been reported to be responsible for drug-induced delirium. We compared the incidence of delirium between two groups of patients who were treated with H(2) blockers (H(2) group) or proton pump inhibitors (PPI group) for anastomotic ulcer prevention following surgical treatment of esophageal cancer. METHOD The incidence and severity of delirium were retrospectively ...

Antiulcer effects of pantoprazole, a proton-pump inhibitor, on water-immersion restraint stress (WIRS)-, alcohol (ethanol)- and pylorus ligation-induced gastric ulcers were investigated in male rats. Rats were orally administered with pantoprazole 30 min prior to exposure to various types of ulcer inducers. In stress-induced ulcer model, rats were subjected to WIRS at 22℃ for 4 hours, and the d...

In the past two decades, increasing consumption of synthetic drugs and its associated side effects has led World Health Organization (WHO) to study the antioxidant activity of this plant. It also conducted an ethno botanical survey of endemic medicinal plants studying its uses by the rural populations in order to prevent and treat many current diseases (1). Achillea species such as Achillea mil...

Gastric ulcers are among the most common diseases affecting humans. This study aimed at investigating the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats. The mechanism by which honey exerts its antiulcer potential was elucidated. Four groups of rats were used: control, ethanol (ulcer), omeprazole, and manuka honey. Stomachs were examined macroscopically ...

Spathodea falcata is used in Indian folk medicine as an antiulcerogenic agent. This study was intended to evaluate the antiulcer property of various extracts of bark of Spathodea falcata at different dose levels in ethanol induced and indomethacin induced gastric ulcer models. It was observed that oral administration of all the extracts shows significant reduction in ulcer lesion index as well ...

Peptic ulcer disease (PUD) is a serious gastrointestinal disorder that requires a well tar­ geted therapeutic strategy. A number of drugs including proton pump inhibitors and H2 Division of Pharmacology, receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation Central Drug Research Institute, of these drugs has shown incidence of relapses, side effects, and ...

The antiulcer and in vitro anti-inflammatory activities of the aerial parts of Enicostemma littorale against aspirin, ethanol, and pyloric ligation-induced ulcers in rats and bovine serum albumin denaturation were studied. The extract (200 mg/kg and 400 mg/kg po) was administered to the overnight fasted rats, one hour prior to aspirin / alcohol / pyloric ligation challenge. The ulcer index, tis...

Diclofenac has been conjugated with different antioxidants having antiulcerogenic activity with the objective of obtaining diclofenac-antioxidant mutual prodrugs as safer NSAIDs devoid of ulcerogenic side-effects. The synthesized derivatives are screened for their antiinflammatory, analgesic and antiulcer activity. The mutual prodrugs show retention of antiinflammatory activity with reduced ulc...

Anti gastric ulcer activity of root, stem and leaves of Amaranthus spinosus Linn. was studied against ethanol, hydrochloric acid, indomethacin, stress and pyloric ligation induced gastric ulceration in albino rats. Omeprazole was used as standard anti gastric ulcer drug. Significant anti gastric ulcer activity was noted in root, stem and leaves of Amaranthus spinosus Linn. Root of the plant, ho...