The present study was designed to investigate the antiulcer activity of ethyl acetate extract of Citrus decumana (grapefruit) peels. The antiulcerogenic activity was evaluated in water immersion and hypothermic restraint stress models at different doses (150, 250 and 350 mg/kg). The antiulcer potential of the extract was assessed by determining and comparing the ulcerative index and biochemical...

Ficus religiosa is being used in Ayurvedic and Malay traditional medicine for the treatment of various diseases including gastric ulcer. Considering the above claims, the present work was undertaken to validate the anti-ulcer potential of the ethanol extract of leaves of Ficus religiosa against in vivo aspirin induced ulcer and pylorus ligation assays. Gastric ulcers induced in Swiss albino rat...

The antiulcer effects of different tricyclic antidepressants (trimipramine, doxepin, imipramine, and amitriptyline) in comparison with those of cimetidine, pirenzepine and omeprazole were investigated in male rats with acute gastric ulcer. Acute gastric ulcer was induced by oral administration of O. 6N HCl solution, 1 mL/rat. Pretreatment of animals with doxepin, trimipramine, amitriptylin...

Study was aimed to evaluate the possible antisecretory and antiulcer activity of crude bark extract of Acacia catechu and its action against indomethacin an non steroidal anti inflammatory drug (NSAID) plus pyloric ligation induced gastric ulcers in rats. Administration of crude extract of Acacia catechu (400mg/kg/day p.o.) significantly reduced ulcer index when compared with indomethacin induc...

Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavono...

Direct gastric mucosal cell damage mediated by nonsteroidal anti-inflammatory drugs (NSAIDs) is involved in the formation of NSAID-induced gastric lesions. We recently suggested that this direct cytotoxicity of NSAIDs is caused by their membrane-permeabilization activity. Geranylgeranylacetone (GGA), a clinically used antiulcer drug, can protect gastric mucosa against lesion formation mediated ...