A large-scale clinical trials was conducted, according to World Health Organization Good Clinical Practice guidelines, in 7 centres in north Cameroon to determine the safety and efficacy of a polyvalent antivenom composed of purified F(ab')2. This study included 223 patients presenting clinically with obvious snake bite, predominantly due to Echis ocellatus (viper), the most abundant species in...

conclusions hemiscorpius lepturus venom in sheep can cause severe changes in some of the coagulation factors. this should be considered as part of the pathogenesis of scorpion sting and seriously in the treatment protocol of scorpion sting victims. results in the studied groups, the effect of time on pt and platelets counts was significant (p < 0.05); however, it did not have a significant effe...

UNLABELLED Recent advances in proteomics enable deep profiling of the compositional details of snake venoms for improved understanding on envenomation pathophysiology and immunological neutralization. In this study, the venom of Australian tiger snake (Notechis scutatus) was trypsin-digested in solution and subjected to nano-ESI-LCMS/MS. Applying a relative quantitative proteomic approach, the ...

BACKGROUND The 20-min whole blood clotting test (WBCT20) is widely used for the identification of coagulopathy in snake envenoming, but its performance in practice has not been evaluated. AIM We aimed to investigate the diagnostic utility of the WBCT20 for coagulopathy in Russell's viper envenoming. DESIGN Prospective observational study. METHODS Adult patients with snake envenoming were ...

BACKGROUND Snakebite has recently been declared a global public health emergency. Empirical data showing the true burden of snakebite is lacking. Treatment with specific antivenoms is considered the only cure. However, several factors have led to an ongoing antivenom crisis. This study offers recommendations concerning the improvement of antivenom access and control, by providing an overview of...

Because it primarily affects the poor in undeveloped parts of the world where medical care is often inadequate and insufficient, envenomation is considered a neglected public health issue, despite the existence of antivenom therapy for more than a century. This article provides an overview of the epidemiological situation for important venomous animals, together with achievements in the product...

BACKGROUND Crotalidae Polyvalent Immune Fab (Ovine) has been the only antivenom commercially available in the US since 2007 for treatment of Crotalinae envenomation. Late coagulopathy can occur or recur after clearance of Fab antivenom, often after hospital discharge, lasting in some cases more than 2 weeks. There have been serious, even fatal, bleeding complications associated with recurrence ...