A bovine alpha s1-casein tryptic hydrolysate was previously demonstrated to display an anxiolytic-like activity in the conditioned defensive burying and in the elevated plus-maze models when i.p. injected. The present study assessed the anxiolytic-like effects of this tryptic hydrolysate after an oral administration in rats faced to the same behavioural situations using diazepam as a reference....

Anxiety and mood disorders have become very significant affections in the last decades. According to WHO at least one mental disease occurred per year in 27% of EU inhabitants (more than 82 mil. people). It is estimated that by 2020, depression will be the main cause of morbidity in the developed countries. These circumstances call for research for new prospective drugs with anxiolytic and anti...

Zingiber officinale belonging to Zingiberaceae family is used worldwide as a cooking spice, condiment and herbal remedy. This study was taken up to investigate the anxiolytic activity of alcohol and water extracts of the rhizomes of Zingiber officinale.in mice, by behavioral tests like elevated plus maze (EPM) and open field test (OFT) which will serve as the basis for assessing anxiolytic effe...

Anxiety disorders are among the most frequent psychiatric disorders. With regard to pharmacological treatment, antidepressants, the calcium modulator pregabalin and benzodiazepines are recommended according to current treatment guidelines. With regard to acute states of anxiety, so far practically only benzodiazepines provide an immediate anxiolytic effect. However, the risk of tolerance and de...

introduction: anxiety is a generalized and extremely unpleasant feeling of vague dread of unknown origin which is accompanied by physical feelings like exhaustion, chest tightness, palpitations, sweating, headache, sudden desire to urinate, restlessness, and a desire to move. anxiety is one of the most common psychiatric disorders which lead to problems in many aspects of individual, family, an...